| Healthy | RA | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
3rd trima | 26 wkpp | pre-conception | 3rd trim | 26 wkpp | ||||||
Median (%) | IQR | Median (%) | IQR | Median (%) | IQR | Median (%) | IQR | Median (%) | IQR | |
Fc | ||||||||||
 Galactosylation | 81.5 | [78.1–83.2] | 71.6 | [67.9–74.7] | 60.8 | [52.2–64.3] | 73.6 | [66.5–79.5] | 61.0 | [56.8–66.7] |
 Sialylation | 18.4 | [17.1–20.5] | 13.1 | [11.5–15.8] | 11.0 | [9.0–13.1] | 16.0 | [14.0–19.7] | 11.5 | [9.4–14.1] |
 Fucosylation | 96.8 | [95.8–97.4] | 97.3 | [96.6–98.0] | 97.9 | [97.5–98.3] | 97.5 | [96.5–98.0] | 97.7 | [97.2–98.2] |
 Bisection | 8.7 | [7.3–9.7] | 9.2 | [8.3–10.5] | 10.3 | [9.0–11.5] | 8.6 | [7.4–10.2] | 11.0 | [9.5–13.4] |
Total | ||||||||||
 Galactosylation | 82.9 | [80.6–84.6] | 74.8 | [70.3–77.0] | 66.0 | [59.9–69.0] | 77.5 | [73.5–82.2] | 68.6 | [59.1–73.5] |
 Sialylation | 26.2 | [23.9–28.7] | 21.3 | [19.4–22.6] | 20.8 | [19.1–23.8] | 27.3 | [24.4–28.4] | 22.6 | [20.0–24.5] |
 Fucosylation | 95.4 | [94.7–96.2] | 96.5 | [95.5–97.2] | 96.9 | [96.2–97.3] | 96.2 | [95.4–96.7] | 96.7 | [96.0–97.1] |
 Bisection | 12.6 | [10.6–14.1] | 14.8 | [13.3–17.3] | 18.1 | [15.8–19.8] | 15.2 | [13.6–17.7] | 18.1 | [16.8–19.6] |
Fab | ||||||||||
 Galactosylation | 96.8 | [96.3–97.0] | 97.2 | [96.5–97.8] | 96.6 | [95.7–97.7] | 97.3 | [96.9–97.8] | 96.8 | [96.0–97.3] |
 Sialylation | 81.6 | [80.4–84.3] | 79.0 | [77.8–82.6] | 79.7 | [77.0–81.1] | 82.7 | [80.6–84.6] | 80.2 | [76.9–81.6] |
 Fucosylation | 70.6 | [68.0–75.3] | 76.6 | [74.5–80.6] | 75.6 | [71.9–80.5] | 73.2 | [61.6–75.8] | 77.7 | [72.8–79.7] |
 Bisection | 37.0 | [36.1–41.4] | 46.6 | [41.7–52.2] | 51.5 | [46.5–55.2] | 42.1 | [33.8–44.4] | 52.2 | [46.7–54.6] |
 % glycosylation | 17.6 | [13.7–21.0] | 16.5 | [13.3–18.2] | 22.0 | [18.7–27.4] | 28.0 | [23.3–32.7] | 21.4 | [19.5–25.4] |