A genetic risk score composed of rheumatoid arthritis risk alleles, HLA-DRB1 haplotypes, and response to TNFi therapy – results from a Swedish cohort study

Table 5 Variance in disease activity changes by genetic risk score, SE and both, in overall RA and in ACPA-positive RA and ACPA-negative RA

Changes from baseline	Overall RA		ACPA-positive RA		ACPA-negative RA
Changes from baseline	R ²	p	R ²	p	R ²	p
GRS_76SNPs
ΔDAS28	0.016747	0.14	0.016816	0.32	0.031191	0.77
ΔCRP	0.008274	0.63	0.007312	0.84	0.098850	0.08
ΔESR	0.005006	0.88	0.003705	0.98	0.063739	0.32
ΔSJC	0.003122	0.96	0.005690	0.91	0.052132	0.44
ΔTJC	0.009859	0.49	0.009595	0.71	0.032586	0.75
ΔVAS global	0.007589	0.67	0.007651	0.82	0.024461	0.87
ΔVAS pain	0.012959	0.30	0.013727	0.48	0.027700	0.82
ΔHAQ	0.019911	0.10	0.034497	0.03	0.019770	0.93
GRS_76SNPs + GRS_AAs + SE
ΔDAS28	0.025706	0.50	0.034035	0.52	0.107155	0.70
ΔCRP	0.016461	0.89	0.014948	0.98	0.159459	0.28
ΔESR	0.017487	0.87	0.016454	0.98	0.104736	0.74
ΔSJC	0.007558	1.00	0.017127	0.96	0.136713	0.42
ΔTJC	0.020931	0.71	0.020560	0.91	0.095691	0.79
ΔVAS global	0.019875	0.76	0.021503	0.89	0.131984	0.47
ΔVAS pain	0.025917	0.50	0.030989	0.63	0.140222	0.39
ΔHAQ	0.029739	0.41	0.054253	0.12	0.115604	0.68

AA amino acid, ACPA anti-citrullinated protein/peptide antibodies, GRS genetic risk score, RA rheumatoid arthritis, SE shared epitope, DAS28 disease activity score 28, CRP C-reactive protein, ESR erythrocyte sedimentation rate, SJC swollen joint count, TJC tender joint count, VAS visual analog scale, HAQ Health Assessment Questionnaire

ISSN: 1478-6362