Table 3 Association of smoking with anti-CCP2, RF antibodies, and anti-CarP in the RA cohorts

  N (total)

428

242

398

276

492

182

 Ever smokers, n (%)

261 (61)

171 (71)

236 (59)

196 (71)

301 (61)

131 (72)

 OR (95% CI)

1 (reference)

1.46 (1.04–2.03)*

1 (reference)

1.68 (1.21–2.33)*

1 (reference)

1.63 (1.12–2.36)*

  p value

–

0.027*

–

<0.001*

–

0.01*

  N (total)

365

404

327

442

420

349

 Ever smokers, n (%)

179 (49)

236 (58)

152 (47)

263 (60)

212 (51)

203 (58)

 OR (95% CI)

1 (reference)

1.46 (1.10–1.94)*

1 (reference)

1.69 (1.27–2.26)*

1 (reference)

1.36 (1.03–1.82)*

  p value

–

0.009*

–

<0.001*

–

0.03*

  N (total)

347

448

339

456

516

279

 Ever smokers, n (%)

180 (52)

291 (65)

183 (54)

288 (63)

288 (56)

183 (66)

 OR (95% CI)

1 (reference)

1.72 (1.29–2.29)*

1 (reference)

1.46 (1.01–1.95)*

1 (reference)

1.51 (1.12 – 2.04)*

  p value

–

<0.001*

–

0.009*

–

0.008*