Table 5 Pooled analysis of the association between smoking and the presence of anti-CCP2, RF, and anti-CarP
Multicenter analysis | Anti-CCP2– RF–anti-CarP– (n = 797) | Anti-CCP2+ RF–anti-CarP– (n = 116) | Anti-CCP2–RF+anti-CarP– (n = 206) | Anti-CCP2–RF–anti-CarP+ (n = 84) | Anti-CCP2+RF+anti-CarP– (n = 309) | Anti-CCP2+RF–anti-CarP+ (n = 75) | Anti-CCP2–RF+anti-CarP+ (n = 45) | Anti-CCP2+RF+anti-CarP+ (n = 606) |
|---|---|---|---|---|---|---|---|---|
Smoking ever, n (%) | 430 (53.9) | 59 (50.9) | 122 (59.2) | 41 (48.8) | 190 (61.5) | 38 (50.7) | 30 (66.7) | 408 (67.3) |
Smoking never, n (%) | 367 (46.1) | 57 (49.1) | 84 (40.8) | 43 (51.2) | 119 (38.5) | 37 (49.3) | 15 (33.3) | 198 (32.7) |
OR (95% CI) | 1 (reference) | 0.83 (0.56–1.24) | 1.25 (0.91–1.71) | 0.81 (0.51–1.28) | 1.40 (1.06–1.84)* | 0.94 (0.58–1.51) | 1.67 (0.88-3.17) | 2.05 (1.53–2.73)* |
p value | – | 0.37 | 0.16 | 0.36 | 0.02* | 0.79 | 0.12 | <0.001* |