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Table 2 Characteristics and levels of VEGF in the various rheumatic diseases

From: Vascular endothelial growth factor levels and rheumatic diseases of the elderly

  RS3PE (n = 5) RA (n = 13) PMR (n = 44) GCA (n = 18) P value Edematous forms (n = 10) Non-edematous forms (n = 70) P value
Age, years, mean ± SD 76.4 ± 9.56 71 ± 7.97 71.41 ± 7.43 76.44 ± 8.07 0.17 76 ± 8.42 72.63 ± 7.95 0.21
Sex, female/male 2/3 8/5 19/25 15/3 0.02a 5/5 39/31 0.74
ESR, mm/h, mean ± SD 50.40 ± 29.84 61.67 ± 39.55 61.24 ± 30.35 82.44 ± 27.34 0.03b 54.89 ± 31.14 66.50 ± 32.10 0.31
CRP, mg/L, mean ± SD 57 ± 35.95 113.62 ± 121.12 73.07 ± 63.11 82.63 ± 62.50 0.81 76.33 ± 54.91 81.38 ± 76.53 0.84
Platelets, Giga/L, mean ± SD 309.60 ± 58.796 334.33 ± 114.20 313.58 ± 104.71 432.56 ± 96.32 0.03c 314.33 ± 63.69 379.29 ± 123.29 0.12
Serum VEGF, pg/ml, median (ITQ) 858 (801–1048) 590 (303–1117) 859.5 (413-1386.5) 882 (671–1131) 0.60 953 (712–1927) 844 (436–1160) 0.34
Plasma VEGF, pg/ml, median (ITQ) 79 (52–94) 90 (47–148) 67 (48–160.5) 120 (69–181) 0.57 108.5 (80.75–146.75) 78 (47–149) 0.58
  1. aSignificant difference (p = 0.02) between PMR and RA on the one hand and PMR and GCA on the other hand; bsignificant difference (p = 0.03) between GCA and RS3PE on the one hand and GCA and PMR on the other hand; csignificant difference (p = 0.03) between GCA and RA on the one hand and GCA and RS3PE on the other hand. VEGF vascular endothelial growth factor, RS3PE remitting symmetrical seronegative synovitis with pitting edema, RA rheumatoid arthritis, PMR polymyalgia rheumatica, GCA giant cell arteritis, SD standard deviation, ITQ interquartile, ESR erythrocyte sedimentation rate, CRP C-reactive protein