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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Granulocyte macrophage colony-stimulating factor receptor α expression and its targeting in antigen-induced arthritis and inflammation

Fig. 3

Effect of granulocyte macrophage colony-stimulating factor receptor α (GM-CSFRα), TNF and IL-6 blockade on myeloid cell populations in antigen-induced peritonitis (AIP). a-c AIP-primed mice were treated with PBS, CAT-004 isotype monoclonal antibody (mAb) or CAM-3003 mAb on day -1. Cells were harvested at day 4 post AIP induction and peritoneal exudate cell (PEC) populations analysed. a GM-CSFRα expression on myeloid cell populations. b Total cells and myeloid cell populations. c MHCII- monocytes/macrophages, MHCII+ macrophages and monocyte-derived dendritic cells (Mo-DCs) as a percentage of CD115+ cells. d AIP-primed mice were treated with anti-TNF mAb, anti-IL-6 mAb or IgG1 isotype mAb on day -1 and day 2. Cells were harvested at day 4 post AIP induction and PEC populations analysed. Total cells and myeloid cell populations are shown. Data are expressed as mean ± SEM; n = 8 mice/group; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 for CAT-004 vs. CAM-3003. cDCs conventional dendritic cells

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