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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Granulocyte macrophage colony-stimulating factor receptor α expression and its targeting in antigen-induced arthritis and inflammation

Fig. 6

In antigen-induced peritonitis (AIP), granulocyte macrophage colony-stimulating factor receptor (GM-CSFR) signalling in monocytes directly regulates monocyte/macrophage/monocyte-derived dendritic cell (Mo-DC) numbers but not Mo-DC development. CD115+ bone marrow monocytes from Csf2rb -/- Csf2rb2 -/- or C57BL/6 wild-type (WT) mice (both CD45.2) were adoptively transferred intraperitoneally (i.p.) to C57BL/6 (CD45.1) mice on day 2 following AIP induction. Peritoneal exudate cells (PECs) were harvested on day 4, i.e., two days following CD115+ cell transfer. a Numbers of donor monocytes/macrophages and Mo-DCs. b Percentage of donor cells that are monocytes/macrophages and Mo-DCs. c Percentage of donor cells that are Ly6C+ vs. Ly6C-. Data are expressed as mean ± SEM; n = 5–7 mice/group; ***p < 0.001, WT vs. Csf2rb -/- Csf2rb2 -/- donor cells

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Arthritis Research & Therapy

ISSN: 1478-6362

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