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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data

Fig. 2

Early longitudinal changes in the three cohorts. Changes in mean clinical and functional scores over the first year from recruitment for 28-joint Disease Activity Score (DAS28) (a, b, c), Health Assessment Questionnaire (HAQ) (d, e, f) and 36-item Short Form Health Survey (SF-36) physical function (g, h, i), stratified by latent class subgroup. Cohorts displayed are the Early Rheumatoid Arthritis Network (ERAN) (a, d, g), British Society for Rheumatology Biologics Registers (BSRBR) tumour necrosis factor (TNF) inhibitor (b, e, h) and BSRBR non-biologic (c, f, i). BL Baseline, 6 m 6 months, 1y 1 year. Complete cases were analysed, yielding respective sample sizes for ERAN, BSRBR TNF inhibitor and BSRBR non-biologic for DAS28 (n = 383, 6376 and 887, respectively), HAQ (n = 447, 5627 and 1601, respectively) and SF-36 physical function (n = 217, 6179 and 1706, respectively). There was significant heterogeneity between the changes in scores of all of the latent classes for each cohort and for each measure (p < 0.001 for each comparison)

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