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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats

Fig. 1

Effects of sodium hyaluronate (Na hyaluronate) and adelmidrol (Adel.) combination on OA pain production and motor function. In the von Frey hair assessment test, the paw withdrawal threshold (PWT) (a) and the paw withdrawal latency (PWL) (b) were prolonged significantly in the inflamed hind paw of the rats given 0.6% adelmidrol + 1.0% sodium hyaluronate and 2% adelmidrol + 1.0% sodium hyaluronate compared with the monosodium iodoacetate (MIA) + solvent group and MIA + sodium hyaluronate 1.0% group. The sham group showed no obvious change. c In the MIA + vehicle and 1.0% sodium hyaluronate groups, the sciatic nerve functionality index (SFI) values were significantly lower than in sham animals. Treatment with a combination of HA acid and adelmidrol improved motor function in a dose-dependent manner. Data are means ± S.E.M. of 10 rats for each group. *P < 0.05 versus sham, °P < 0.05 versus MIA + vehicle

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