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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats

Fig. 6

Effects of hyaluronic acid and adelmidrol combination on the pathogenesis of subchondral bone. In the monosodium iodoacetate (MIA) + solvent (b) and MIA + 1.0% sodium (Na) hyaluronate (c) knee groups, the number of osteoclasts was increased after MIA injection. Compared with knee joints in the MIA + solvent group, knees in the 0.6% adelmidrol (Adelm) + 1.0% sodium hyaluronate (d) group exhibited moderately increased numbers of osteoclasts. The higher treatment dose of 2% adelmidrol + 1.0% sodium hyaluronate showed no statistical improvement in cell numbers (e). There is no variation in cell numbers in sham knee joints (a). f Cell number per joint. g Moreover to quantify the structural changes in the subchondral bone in MIA-induced OA, each rat was scanned for bone volume density (mm3 ). Compared with the MIA + solvent and MIA + 1.0% sodium hyaluronate groups, 0.6% adelmidrol + 1.0% sodium hyaluronate and higher treatment dose of 2% adelmidrol + 1.0% sodium hyaluronate showed a marked increase in bone volume. Thus, treatment with 0.6% adelmidrol + 1.0% sodium hyaluronate and a higher treatment dose of 2% adelmidrol + 1.0% sodium hyaluronate showed significant and dose-dependent effects on MIA-induced deterioration of the subchondral bone. Data are means ± SEM of 10 rats for each group. *P < 0.05 versus sham, °P < 0.05 versus MIA + vehicle

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