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Fig. 7 | Arthritis Research & Therapy

Fig. 7

From: Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats

Fig. 7

Effects of hyaluronic acid and adelmidrol combination on histological features of osteoarthritis (OA) knee tissue. MIA-induced OA and tissue sample processing were carried out as detailed in the Methods section. Knee sections from sham rats displayed normal architecture of the joint tissue (a; see Mankin Score in f). The MIA + solvent (b) and MIA + 1.0% sodium hyaluronate (c) groups showed surface layer fibrillation, a decrease in blood cells, multilayering in transition and radial zones, no pannus formation, and modified Mankin scores. The combination of HA and adelmidrol at the doses indicated (0.6% adelmidrol + 1.0% sodium hyaluronate (d), and 2% adelmidrol + 1.0% sodium hyaluronate (e)) reduced histological alterations induced by administration of MIA. Histological scoring was performed by an independent observer (f). Data are means ± SEM of 10 rats for each group. *P < 0.05 versus sham, °P < 0.05 versus MIA + vehicle

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