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Table 2 Analysis of associations between interferon score and clinical parameters after 1000-times random sampling

From: Type I interferon response gene expression in established rheumatoid arthritis is not associated with clinical parameters

Ā 

Complete group (nā€‰=ā€‰182)

Cross-validation

p Value

BH-corrected

p value

Significant results (pā€‰<ā€‰0.05)

Median p values

Both sets

One set

Neither set

Set 1

Set 2

Disease parameters

ā€ƒDisease duration

0.061

0.25

0

371

629

0.18

0.20

ā€ƒDAS28

0.18

0.41

0

199

801

0.38

0.32

ā€ƒTJC28

0.10

0.36

0

264

736

0.25

0.25

ā€ƒSJC28

0.61

0.76

1

39

960

0.53

0.59

ā€ƒVAS

0.21

0.44

0

122

878

0.39

0.35

ā€ƒErosions

0.41

0.60

0

61

939

0.50

0.51

ā€ƒNodules

0.24

0.46

1

143

856

0.39

0.41

Laboratory parameters

ā€ƒESR

0.86

0.98

6

18

976

0.60

0.58

ā€ƒESR dichotomous (>20)

0.71

0.85

0

19

981

0.60

0.58

ā€ƒCRP

0.14

0.39

0

233

767

0.30

0.29

ā€ƒCRP dichotomous (ā‰„10)

0.15

0.38

0

190

810

0.30

0.33

ā€ƒRF titer

0.36

0.60

1

66

933

0.46

0.50

ā€ƒRF positivity

0.96

1.0

3

3

994

0.62

0.61

ā€ƒACPA titer

0.38

0.59

0

64

936

0.47

0.51

ā€ƒACPA positivity

0.86

0.98

1

9

990

0.64

0.64

ā€ƒACPA high positivity (ā‰„3Ɨ cutoff)

0.29

0.52

0

79

921

0.44

0.44

ā€ƒRF- and ACPA-positive vs. rest

0.57

0.79

0

34

966

0.59

0.58

ā€ƒRF- and ACPA-negative vs. rest

0.13

0.41

0

219

781

0.27

0.28

Medication parameters

ā€ƒMTX use

Ā Ā 

2

3

995

0.66

0.65

ā€ƒMTX dosage

0.57

0.79

1

29

970

0.58

0.58

ā€ƒPrednisone use

0.037

0.19

0

526

474

0.14

0.14

ā€ƒPrednisone dosage

0.017

0.14

0

718

282

0.092

0.090

ā€ƒHCQ use

0.001

0.013

521

479

0

0.015

0.015

ā€ƒSSZ use

0.023

0.14

0

584

416

0.11

0.11

ā€ƒPREDN and/or HCQ and/or SSZ use

0.00032

0.0080

612

388

0

0.012

0.010

  1. Abbreviations: BH Benjamini-Hochberg, HCQ Hydroxychloroquine, SSZ Sulfasalazine, PREDN Prednisone, ACPA Anti-citrullinated protein antibodies, CRP C-reactive protein, DAS28 28-joint Disease Activity Score, DMARD Disease-modifying antirheumatic drug, ESR Erythrocyte sedimentation rate, RF Rheumatoid factor, MTX Methotrexate, SJC28 Swollen joint count in 28 joints, TJC28 Tender joint count in 28 joints, VAS Visual analogue scale