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Table 2 Analysis of associations between interferon score and clinical parameters after 1000-times random sampling

From: Type I interferon response gene expression in established rheumatoid arthritis is not associated with clinical parameters

  Complete group (n = 182) Cross-validation
p Value BH-corrected
p value
Significant results (p < 0.05) Median p values
Both sets One set Neither set Set 1 Set 2
Disease parameters
 Disease duration 0.061 0.25 0 371 629 0.18 0.20
 DAS28 0.18 0.41 0 199 801 0.38 0.32
 TJC28 0.10 0.36 0 264 736 0.25 0.25
 SJC28 0.61 0.76 1 39 960 0.53 0.59
 VAS 0.21 0.44 0 122 878 0.39 0.35
 Erosions 0.41 0.60 0 61 939 0.50 0.51
 Nodules 0.24 0.46 1 143 856 0.39 0.41
Laboratory parameters
 ESR 0.86 0.98 6 18 976 0.60 0.58
 ESR dichotomous (>20) 0.71 0.85 0 19 981 0.60 0.58
 CRP 0.14 0.39 0 233 767 0.30 0.29
 CRP dichotomous (≥10) 0.15 0.38 0 190 810 0.30 0.33
 RF titer 0.36 0.60 1 66 933 0.46 0.50
 RF positivity 0.96 1.0 3 3 994 0.62 0.61
 ACPA titer 0.38 0.59 0 64 936 0.47 0.51
 ACPA positivity 0.86 0.98 1 9 990 0.64 0.64
 ACPA high positivity (≥3× cutoff) 0.29 0.52 0 79 921 0.44 0.44
 RF- and ACPA-positive vs. rest 0.57 0.79 0 34 966 0.59 0.58
 RF- and ACPA-negative vs. rest 0.13 0.41 0 219 781 0.27 0.28
Medication parameters
 MTX use    2 3 995 0.66 0.65
 MTX dosage 0.57 0.79 1 29 970 0.58 0.58
 Prednisone use 0.037 0.19 0 526 474 0.14 0.14
 Prednisone dosage 0.017 0.14 0 718 282 0.092 0.090
 HCQ use 0.001 0.013 521 479 0 0.015 0.015
 SSZ use 0.023 0.14 0 584 416 0.11 0.11
 PREDN and/or HCQ and/or SSZ use 0.00032 0.0080 612 388 0 0.012 0.010
  1. Abbreviations: BH Benjamini-Hochberg, HCQ Hydroxychloroquine, SSZ Sulfasalazine, PREDN Prednisone, ACPA Anti-citrullinated protein antibodies, CRP C-reactive protein, DAS28 28-joint Disease Activity Score, DMARD Disease-modifying antirheumatic drug, ESR Erythrocyte sedimentation rate, RF Rheumatoid factor, MTX Methotrexate, SJC28 Swollen joint count in 28 joints, TJC28 Tender joint count in 28 joints, VAS Visual analogue scale