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Table 6 WORMS scoring of MRI of the knee at each visit

From: Efficacy and safety of adult human bone marrow-derived, cultured, pooled, allogeneic mesenchymal stromal cells (Stempeucel®): preclinical and clinical trial in osteoarthritis of the knee joint

WORMS

25 M

50 M

P1

P value

75 M

150 M

P2

P value

Baseline

67.0 (19.8)

78.8 (40.9)

76.5 (23.5)

71.3 (21.4)

62.0 (17.9)

70.8 (14.7)

6 months

67.5 (20.5)

77.9 (41.2)

74.9 (22.4)

0.5521

71.4 (20.9)

62.0 (17.7)

69.9 (14.3)

0.7360

12 months

66.1 (19.2)

78.0 (41.1)

74.9 (22.5)

0.5310

67.0 (20.9)

60.6 (15.7)

72.3 (15.2)

0.0609

  1. Values are shown as mean (SD)
  2. The range of WORMS score used in this study was 0–314
  3. 25 M, 50 M, 75 M, 150 M = 25, 50, 75, 150 million cells, respectively
  4. P1, P2 = Placebo 1 and 2, respectively
  5. MRI magnetic resonance imaging, WORMS whole-organ magnetic resonance imaging score