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Table 1 Changes in clinical measures of disease activity over 12 weeks on anti-TNF treatment in 25 patients with rheumatoid arthritis

From: Increase in circulating Th17 cells during anti-TNF therapy is associated with ultrasonographic improvement of synovitis in rheumatoid arthritis

Parameter

Baseline

Week 1

Week 4

Week 12

 

Mean ± SD

Mean ± SD

P value

Mean ± SD

P value

Mean ± SD

P value

DAS28-ESR

5.72 ± 0.84

4.47 ± 1.14

****

4.26 ± 1.13

****

2.87 ± 1.11

****

DAS28-CRP

5.28 ± 0.98

3.98 ± 1.09

****

3.85 ± 1.13

****

2.36 ± 1.04

****

SJC28

7.68 ± 5.36

4.42 ± 3.89

**

4.54 ± 4.28

**

3.00 ± 3.83

***

TJC28

14.88 ± 8.51

8.95 ± 6.66

***

8.76 ± 6.69

**

4.68 ± 4.93

***

CRP

15.74 ± 18.26

5.29 ± 6.39

***

10.75 ± 24.15

***

8.73 ± 16.48

***

ESR

27.21 ± 22.67

20.50 ± 19.36

**

19.96 ± 14.88

**

20.45 ± 16.73

ns

  1. Data are presented as mean ± SD. DAS28 disease activity score in 28 joints, ESR erythrocyte sedimentation rate, CRP C-reactive protein, SJC28 swollen joint count out of 28 joints, TJC28 tender joint count out of 28 joints
  2. Each time point on treatment was compared to baseline using Wilcoxon matched pairs test; **P < 0.001, ***P < 0.0005, ****P < 0.0001