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Table 1 Patient characteristics

From: Optimal regimens of sulfamethoxazole-trimethoprim for chemoprophylaxis of Pneumocystis pneumonia in patients with systemic rheumatic diseases: results from a non-blinded, randomized controlled trial

 

SS

(n = 58)

HS

(n = 59)

ES

(n = 55)

Age, years

58.5 ± 15.0

58.1 ± 15.9

60.1 ± 14.4

Female, %

63.8

64.4

70.9

Body weight, kg

55.9 ± 11.8

56.8 ± 10.9

54.5 ± 9.9

Diagnosis

 RA, %

8.6

6.8

7.3

 SLE, %

10.3

11.9

10.9

 PM/DM, %

19.0

37.3

29.1

 Vasculitis syndrome, %

44.8

25.4

30.9

 Othersa, %

17.2

18.6

21.8

Disease duration, months (IQR)

2 (1–5)

3 (2–7)

4 (2–9)

Comorbidities, %

72.4

79.7

78.2

 ILD, %

38.0

44.1

43.6

 Other lung comorbiditiesb, %

12.1

8.5

5.5

 Hypertension, %

13.8

18.6

14.5

 Diabetes, %

6.9

5.1

14.5

 CVDc, %

3.4

5.1

5.5

 CKD, %

1.7

0

0

 Malignancies, %

6.9

11.9

9.1

 Others, %

41.4

42.3

36.4

Baseline laboratory data

 WBC, /μL (NR, 3300‒8600)

10401 ± 5359

9901 ± 4767

9743 ± 5177

 Lymphocyte, /μL

1766 ± 1106

1933 ± 1244

1656 ± 877

 IgG, mg/dL (NR, 861‒1747)

1676 ± 677

1668 ± 679

2006 ± 1945

Treatment before enrollmentd

 CS, %

15.5

13.3

14.5

 Dosage of CSe, mg/day (IQR)

13.8 (5–15)

8.8 (5–10.6)

6.8 (5–8.125)

 ISf, %

1.7

3.2

7.3

 Biologics, %

1.7

0

0

Dosage of concomitant CS

 At baseline, mg/kg/day (IQR)

0.97 (0.89–1.01)

0.97 (0.81–1.02)

0.94 (0.75–1.05)

 At week 24, mg/day (IQR)

12.5 (10–14.25)

11 (9–15)

10 (9–12.5)

Other immunosuppressive treatment between weeks 0 and 12

 IV pulsed mPSL, %

20.6

32.2

20

 IS, %

70.6

67.8

81.8

 Biologics, %

1.7

3.4

1.8

Other immunosuppressive treatment between weeks 12 and 24

 IV pulsed mPSL, %

1.7

3.4

0

 IS, %

65.5

72.9

78.2

 Biologics, %

1.7

1.7

3.6

  1. Values that conform to the normal distribution are expressed as the mean ± SD. Values that do not conform to the normal distribution are expressed as the median (interquartile range). aOthers include systemic sclerosis, mixed connective tissue diseases, Sjogren’s syndrome, adult-onset Still’s disease, relapsing polychondritis, IgG4-related disease, and antiphospholipid syndrome. bOther lung comorbidities include chronic obstructive lung disease, bronchiectasis, bronchial asthma, pulmonary hypertension, and old tuberculosis. cCardiovascular diseases include cerebral infarction, cerebral hemorrhage, myocardial infarction, and angina pectoris. dTreatment between 84 days and 1 day before starting or intensifying immunosuppressive treatment. ePrednisolone equivalent dose. fImmunosuppressive drugs include azathioprine, cyclophosphamide, cyclosporine, methotrexate, mizoribine, and mycophenolate mofetil, and tacrolimus. SS the single-strength dosage group, HS the half-strength dosage group, ES the escalation dosage group, RA rheumatoid arthritis, SLE systemic lupus erythematosus, PM polymyositis, DM dermatomyositis, IQR interquartile range, ILD interstitial lung disease, CVD cardiovascular disease, CKD chronic kidney disease, WBC white blood cell, NR normal range, CS corticosteroids, mPSL methylpredonisolone, IS immunosuppressive drugs, IV intravenous