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Table 4 Baseline clinical and demographic data between RA patients with or without pneumonia

From: The 23-valent pneumococcal polysaccharide vaccine in patients with rheumatoid arthritis: a double-blinded, randomized, placebo-controlled trial

 

Pneumonia

Without pneumonia

 

(n = 32)

(n = 868)

P value

Demographics

 Age (years)

68.6 ± 10.8

62.8 ± 11.9

0.010

 Gender, male/female

7 (21.9%)/25 (78.1%)

189 (21.8%)/679 (78.2%)

0.989

 Smoking history

7 (21.9%)

199 (22.9%)

0.889

Laboratory data

 CRP (mg/dl)

1.14 ± 2.29

0.48 ± 0.97

0.023

 Serum albumin (g/dl)

3.95 ± 0.44

4.07 ± 0.37

0.210

 Serum creatinine (mg/dl)

0.70 ± 0.21

0.68 ± 0.31

0.248

RA characteristics

 RA duration (years)

12.3 ± 8.3

11.9 ± 10.1

0.378

 HAQ

0.78 ± 0.81

0.66 ± 0.74

0.564

 DAS28 (CRP)

2.32 ± 0.97

2.48 ± 1.13

0.548

 SDAI

6.72 ± 6.11

8.41 ± 8.20

0.237

 CDAI

5.64 ± 4.76

7.94 ± 7.94

0.123

Comorbidity

 Cardiovascular disease

13 (40.6%)

245 (28.2%)

0.128

  CVA

2 (6.3%)

22 (2.5%)

0.209

  Ischemic heart disease

1 (3.1%)

17 (2.0%)

0.482

  Hypertension

10 (31.3%)

215 (24.8%)

0.406

  Arrythmia

2 (6.3%)

9 (1.0%)

0.055

  Cardiac failure

2 (6.3%)

8 (0.9%)

0.046

 Metabolic disease

10 (31.3%)

197 (22.7%)

0.259

  Hyperlipidemia

6 (18.8%)

122 (14.1%)

0.297

  Hyperuricemia

0

9 (1.0%)

0.721

  Diabetes

5 (15.6%)

88 (10.1%)

0.229

 CKD

2 (6.3%)

33 (3.8%)

0.356

 Autoimmune disease

1 (3.1%)

36 (4.1%)

0.617

 Rheumatoid lung

14 (43.8%)

138 (15.9%)

<0.0001

  Interstitial pneumonia

11 (34.4%)

91 (10.5%)

<0.0001

  Bronchial lesion

3 (9.4%)

35 (4.0%)

0.148

  Pleural lesion

1 (3.1%)

11 (1.3%)

0.354

 COPD

0

27 (3.1%)

0.371

 NTM

1 (3.1%)

14 (1.6%)

0.422

PPSV23 vaccination

17 (53.1%)

447 (51.5%)

0.856

Treatment

 PSL

18 (56.3%)

438 (50.5%)

0.520

  Dose of prednisolone (mg/day)

5.61 ± 4.90

4.58 ± 2.69

0.521

 MTX

20 (62.5%)

584 (67.3%)

0.572

 Dose of MTX (mg/week)

7.90 ± 2.38

8.18 ± 2.82

0.660

 TAC

4 (12.5%)

116 (13.4%)

0.573

 Biologics

14 (43.8%)

496 (57.1%)

0.133

  1. Data presented as number (percentage) or mean ± standard deviation
  2. PPSV23 23-valent pneumococcal polysaccharide vaccine, CRP C-reactive protein, RA rheumatoid arthritis, HAQ Health Assessment Questionnaire Disability Index score, DAS28 Disease Activity Score 28, SDAI simplified disease activity index, CDAI clinical disease activity index, CVA cerebrovascular accident, CKD chronic kidney disease, COPD chronic obstructive pulmonary disease, NTM nontuberculous mycobacteria, PSL prednisolone, MTX methotrexate, TAC tacrolimus