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Table 4 Baseline clinical and demographic data between RA patients with or without pneumonia

From: The 23-valent pneumococcal polysaccharide vaccine in patients with rheumatoid arthritis: a double-blinded, randomized, placebo-controlled trial

  Pneumonia Without pneumonia  
(n = 32) (n = 868) P value
Demographics
 Age (years) 68.6 ± 10.8 62.8 ± 11.9 0.010
 Gender, male/female 7 (21.9%)/25 (78.1%) 189 (21.8%)/679 (78.2%) 0.989
 Smoking history 7 (21.9%) 199 (22.9%) 0.889
Laboratory data
 CRP (mg/dl) 1.14 ± 2.29 0.48 ± 0.97 0.023
 Serum albumin (g/dl) 3.95 ± 0.44 4.07 ± 0.37 0.210
 Serum creatinine (mg/dl) 0.70 ± 0.21 0.68 ± 0.31 0.248
RA characteristics
 RA duration (years) 12.3 ± 8.3 11.9 ± 10.1 0.378
 HAQ 0.78 ± 0.81 0.66 ± 0.74 0.564
 DAS28 (CRP) 2.32 ± 0.97 2.48 ± 1.13 0.548
 SDAI 6.72 ± 6.11 8.41 ± 8.20 0.237
 CDAI 5.64 ± 4.76 7.94 ± 7.94 0.123
Comorbidity
 Cardiovascular disease 13 (40.6%) 245 (28.2%) 0.128
  CVA 2 (6.3%) 22 (2.5%) 0.209
  Ischemic heart disease 1 (3.1%) 17 (2.0%) 0.482
  Hypertension 10 (31.3%) 215 (24.8%) 0.406
  Arrythmia 2 (6.3%) 9 (1.0%) 0.055
  Cardiac failure 2 (6.3%) 8 (0.9%) 0.046
 Metabolic disease 10 (31.3%) 197 (22.7%) 0.259
  Hyperlipidemia 6 (18.8%) 122 (14.1%) 0.297
  Hyperuricemia 0 9 (1.0%) 0.721
  Diabetes 5 (15.6%) 88 (10.1%) 0.229
 CKD 2 (6.3%) 33 (3.8%) 0.356
 Autoimmune disease 1 (3.1%) 36 (4.1%) 0.617
 Rheumatoid lung 14 (43.8%) 138 (15.9%) <0.0001
  Interstitial pneumonia 11 (34.4%) 91 (10.5%) <0.0001
  Bronchial lesion 3 (9.4%) 35 (4.0%) 0.148
  Pleural lesion 1 (3.1%) 11 (1.3%) 0.354
 COPD 0 27 (3.1%) 0.371
 NTM 1 (3.1%) 14 (1.6%) 0.422
PPSV23 vaccination 17 (53.1%) 447 (51.5%) 0.856
Treatment
 PSL 18 (56.3%) 438 (50.5%) 0.520
  Dose of prednisolone (mg/day) 5.61 ± 4.90 4.58 ± 2.69 0.521
 MTX 20 (62.5%) 584 (67.3%) 0.572
 Dose of MTX (mg/week) 7.90 ± 2.38 8.18 ± 2.82 0.660
 TAC 4 (12.5%) 116 (13.4%) 0.573
 Biologics 14 (43.8%) 496 (57.1%) 0.133
  1. Data presented as number (percentage) or mean ± standard deviation
  2. PPSV23 23-valent pneumococcal polysaccharide vaccine, CRP C-reactive protein, RA rheumatoid arthritis, HAQ Health Assessment Questionnaire Disability Index score, DAS28 Disease Activity Score 28, SDAI simplified disease activity index, CDAI clinical disease activity index, CVA cerebrovascular accident, CKD chronic kidney disease, COPD chronic obstructive pulmonary disease, NTM nontuberculous mycobacteria, PSL prednisolone, MTX methotrexate, TAC tacrolimus