Fig. 1

Hierarchical clustering of genes that were upregulated (a) and downregulated (b) at least twofold in baseline systemic juvenile idiopathic arthritis (SJIA) samples compared with healthy control samples. Subjects are shown in columns and genes (probe sets) are shown in rows. Relative gene expression values are color-coded. With upregulated probe sets the hierarchical clustering of subjects perfectly segregated patients with SJIA from healthy controls. Using downregulated genes, the majority of patients with SJIA clustered together; however, a subset of patients with SJIA was indistinguishable from healthy controls