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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: TIM-1 defines a human regulatory B cell population that is altered in frequency and function in systemic sclerosis patients

Fig. 1

T cell Ig and mucin domain protein 1 (TIM-1) expression by healthy and systemic sclerosis (SSc) B cell subpopulations. a Left representative dot-plot indicating the gating strategy to identify transitional, naïve, memory, and plasmablast B cell subpopulations according to the expression of CD24 and CD38. Middle representative histograms show the expression of TIM-1 in different B cell subpopulations. Right percentage of TIM-1-expressing B cells from healthy donors in each indicated subpopulation, n = 7. b. Representative dot-plots (left) and graph (right) show the frequency of TIM-1+ cells on different B cell subpopulations from healthy subjects and patients with SSc. c Correlation between the expression levels of TIM-1 and CD19 in transitional B cells from patients with SSc. FMO fluorescence minus one staining control, MFI mean fluorescence intensity. *P < 0.05, ***P < 0.001

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