Variable | Muscle IL-6 | Muscle IL-8 | Muscle TNF-α | Muscle IL-1β | Muscle TLR-4 |
---|---|---|---|---|---|
Age (years) | −0.07 | 0.05 | 0.09 | −0.09 | −0.29 * |
BMI (kg/m2) | 0.24 | −0.05 | −0.23 | −0.10 | −0.25 |
Disease activity (DAS28) | 0.23 | 0.30 * | 0.14 | 0.35 * | −0.01 |
Disability (HAQ-DI) | 0.33 * | 0.19 | 0.09 | 0.33 * | 0.12 |
Pain (VAS) | 0.15 | 0.17 | 0.29 * | 0.39 * | 0.47 * |
Prednisone use (yes = 1) | 0.14 | −0.05 | 0.00 | 0.01 | −0.01 |
DMARD use (yes = 1) | −0.04 | −0.07 | −0.30 | 0.21 | 0.08 |
Biologic use (yes = 1) | −0.25 | −0.37 * | 0.21 | −0.33 * | 0.01 |
Comorbidity index | 0.17 | 0.12 | 0.17 | 0.26 | −0.08 |
Plasma hsCRP (mg/L) | 0.20 | 0.07 | 0.11 | −0.03 | −0.17 |
Plasma IL-1β (pg/mL) | 0.01 | −0.07 | −0.07 | −0.14 | −0.12 |
Plasma IL-6 (pg/mL) | −0.03 | 0.11 | 0.12 | −0.01 | −0.10 |
Plasma IL-8 (pg/mL) | −0.11 | 0.06 | 0.11 | 0.14 | 0.02 |
Plasma TNF-α (pg/mL) | −0.37 * | −0.15 | 0.02 | −0.23 | −0.08 |
Plasma IL-18 (pg/mL) | −0.08 | −0.12 | −0.02 | −0.24 | 0.06 |
GlycA (μmol/L) | 0.41 * | 0.38 * | −0.06 | 0.07 | −0.21 |
HOMA | 0.11 | 0.04 | −0.06 | −0.10 | −0.07 |
Insulin sensitivity (10-5.min-1/(pmol/L)) | −0.20 | −0.19 | −0.06 | −0.09 | −0.18 |
Fasting insulin (mU/L) | 0.13 | 0.09 | −0.13 | −0.06 | −0.06 |
Visceral adiposity (cm2) | 0.11 | 0.01 | −0.28 | 0.03 | −0.23 |
Abdominal subcutaneous adiposity (cm2) | 0.21 | 0.06 | −0.19 | −0.06 | −0.19 |
Total abdominal adiposity (cm2) | 0.19 | 0.07 | −0.24 | −0.06 | −0.28 |
Thigh muscle density (Hu) | −0.04 | −0.10 | 0.06 | 0.16 | 0.28 * |
Thigh inter-muscular adiposity (cm2) | 0.12 | 0.01 | −0.08 | −0.11 | −0.12 |
Thigh subcutaneous adiposity (cm2) | 0.31 * | −0.07 | −0.11 | −0.09 | −0.11 |
Exercise (min/day) | −0.40 * | −0.38 * | −0.05 | −0.38 * | −0.11 |
Physical activity (MET h/day) | −0.33 * | −0.26 | 0.10 | −0.35 * | −0.15 |