Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability

Table 3 Canonical pathways implicated in gene expression in muscle in rheumatoid arthritis

Pathway	Dataset genes^a in pathway (n)	Total genes in pathway (n)	Z-score	p value
Wnt/Ca + pathway	5	55	0	0.006
Netrin signaling	4	39	NaN	0.008
Glycolysis	3	24	NaN	0.013
Atherosclerosis signaling	7	121	NaN	0.013
Altered T and B cell signaling in rheumatoid arthritis	5	81	NaN	0.023
Methionine degradation to homocysteine	2	16	NaN	0.043
PI3K signaling in B lymphocytes	6	123	−0.816	0.043
April mediated signaling	3	38	NaN	0.044
B cell activating factor signaling	3	40	NaN	0.049

^aDataset genes were those differentially expressed between 20 patients with rheumatoid arthritis and 20 age, gender, and body mass index matched controls (p < 0.02). NaN Not a number

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