Skip to main content

Table 3 Canonical pathways implicated in gene expression in muscle in rheumatoid arthritis

From: Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability

Pathway Dataset genesa in pathway (n) Total genes in pathway (n) Z-score p value
Wnt/Ca + pathway 5 55 0 0.006
Netrin signaling 4 39 NaN 0.008
Glycolysis 3 24 NaN 0.013
Atherosclerosis signaling 7 121 NaN 0.013
Altered T and B cell signaling in rheumatoid arthritis 5 81 NaN 0.023
Methionine degradation to homocysteine 2 16 NaN 0.043
PI3K signaling in B lymphocytes 6 123 −0.816 0.043
April mediated signaling 3 38 NaN 0.044
B cell activating factor signaling 3 40 NaN 0.049
  1. aDataset genes were those differentially expressed between 20 patients with rheumatoid arthritis and 20 age, gender, and body mass index matched controls (p < 0.02). NaN Not a number