| Disease activity | Disability | Pain | Exercise (min/d) | Physical activity (MET h/d) |
---|---|---|---|---|---|
Amino acids | Â | Â | Â | Â | Â |
Glycine | 0.33b | 0.50a | 0.23 | 0.11 | 0.02 |
Alanine | -0.31b | 0.03 | -0.01 | 0.11 | 0.08 |
Serine | 0.31b | 0.20 | 0.17 | -0.03 | -0.01 |
Proline | 0.20 | 0.36a | 0.09 | 0.05 | 0.08 |
Valine | 0.12 | 0.11 | -0.04 | 0.05 | -0.01 |
Leucine/isoleucine | 0.09 | 0.18 | -0.01 | -0.08 | -0.16 |
Methionine | 0.07 | 0.16 | -0.17 | -0.01 | -0.04 |
Histidine | -0.08 | -0.02 | -0.12 | 0.23 | 0.19 |
Phenylalanine | -0.06 | -0.04 | -0.21 | 0.06 | 0.04 |
Tyrosine | -0.06 | 0.08 | -0.13 | 0.13 | 0.14 |
Aspartate/asparagine | 0.34b | 0.36a | 0.20 | -0.13 | -0.12 |
Glutamate/glutamine | 0.20 | 0.24 | 0.06 | -0.12 | -0.04 |
Ornithine | 0.32b | 0.39a | 0.14 | -0.21 | -0.20 |
Citrulline | 0.08 | 0.21 | 0.13 | -0.02 | 0.13 |
Arginine | 0.27 | 0.45a | 0.24 | -0.26 | -0.27 |
Organic acids | Â | Â | Â | Â | Â |
Lactate | -0.09 | -0.18 | -0.06 | -0.09 | -0.12 |
Pyruvate | -0.22 | -0.22 | -0.21 | 0.16 | 0.05 |
Succinate | 0.03 | -0.01 | 0.15 | -0.06 | -0.12 |
Fumarate | -0.34b | -0.24 | -0.15 | 0.05 | -0.01 |
Malate | -0.28 | -0.14 | 0.04 | -0.01 | -0.07 |
alphaKetoglutarate | -0.22 | -0.03 | -0.03 | 0.27 | 0.18 |
Citrate | 0.17 | 0.23 | 0.29 | 0.05 | 0.14 |
Acylcarnitines | Â | Â | Â | Â | Â |
Free carnitine: C0 | -0.10 | 0.19 | 0.10 | 0.04 | 0.08 |
C2 | -0.07 | 0.08 | 0.07 | -0.22 | -0.02 |
C3 | -0.05 | 0.10 | -0.01 | 0.10 | 0.00 |
C4/Ci4 | -0.02 | -0.13 | -0.20 | 0.09 | 0.16 |
C5:1 | 0.15 | 0.09 | 0.06 | -0.10 | 0.05 |
C5 | 0.01 | 0.05 | -0.24 | 0.14 | 0.10 |
C4OH | 0.11 | 0.09 | 0.11 | -0.11 | -0.04 |
C6 | 0.05 | -0.10 | -0.24 | 0.30 | 0.29 |
C5OH | -0.24 | 0.04 | 0.14 | 0.14 | 0.25 |
C3DC | -0.17 | 0.13 | 0.03 | -0.02 | 0.10 |
C4DC/Ci4DC | 0.02 | 0.28b | 0.05 | -0.32b | -0.23 |
C8:1 | -0.10 | -0.05 | -0.15 | -0.07 | 0.00 |
C8 | 0.01 | -0.11 | -0.13 | 0.16 | 0.13 |
C5DC | 0.19 | 0.20 | 0.03 | -0.12 | -0.11 |
C8:1OH/C6:1Â DC | 0.11 | 0.21 | 0.12 | -0.05 | -0.11 |
C6DC/C8OH | -0.02 | 0.03 | -0.10 | 0.08 | 0.11 |
C10:3 | 0.02 | 0.15 | 0.15 | -0.10 | -0.09 |
C10:2 | 0.00 | 0.06 | -0.05 | -0.14 | -0.20 |
C10:1 | -0.09 | -0.09 | -0.08 | 0.19 | 0.11 |
C10 | -0.05 | -0.12 | -0.13 | 0.15 | 0.14 |
C7DC | 0.04 | 0.13 | 0.06 | -0.20 | -0.20 |
C8:1Â DC | -0.17 | -0.03 | -0.13 | -0.06 | -0.09 |
C10OH:C8DC | -0.08 | 0.00 | -0.15 | 0.06 | 0.07 |
C12:2 | 0.04 | -0.01 | -0.08 | -0.24 | -0.26 |
C12:1 | -0.14 | -0.12 | -0.13 | 0.14 | 0.12 |
C12 | -0.20 | -0.22 | -0.19 | 0.20 | 0.19 |
C12:2OH/C10:2Â DC | -0.19 | -0.03 | -0.14 | 0.06 | 0.00 |
C12:1OH/C10:1Â DC | -0.19 | -0.07 | -0.16 | 0.15 | 0.18 |
C12OH/C10DC | -0.16 | 0.03 | -0.13 | 0.13 | 0.14 |
C14:3 | -0.14 | -0.09 | -0.15 | 0.19 | 0.20 |
C14:2 | -0.22 | -0.17 | -0.22 | 0.27 | 0.26 |
C14:1 | -0.18 | -0.16 | -0.17 | 0.21 | 0.21 |
C14 | -0.25 | -0.21 | -0.26 | 0.24 | 0.22 |
C14:3OH/C12:3Â DC | -0.05 | 0.08 | -0.01 | -0.03 | 0.12 |
C14:2OH/C12:2Â DC | -0.12 | -0.03 | -0.20 | 0.04 | 0.03 |
C14:1OH/C12:1Â DC | -0.24 | -0.11 | -0.19 | 0.14 | 0.17 |
C14OH/C12DC | -0.13 | 0.03 | -0.14 | 0.16 | 0.17 |
C16:3 | -0.28 | -0.19 | -0.22 | 0.26 | 0.27 |
C16:2 | -0.34b | -0.26 | -0.26 | 0.35a | 0.33b |
C16:1 | -0.28 | -0.22 | -0.17 | 0.22 | 0.18 |
C16 | -0.27 | -0.20 | -0.19 | 0.17 | 0.18 |
C16:3OH/C14:3-DC | -0.16 | -0.10 | -0.03 | 0.11 | 0.19 |
C16:2OH/C14:2Â DC | -0.26 | -0.16 | -0.19 | 0.12 | 0.10 |
C16:1OH/C14:1Â DC | -0.25 | -0.09 | -0.21 | 0.10 | 0.12 |
C16OH/C14DC | -0.17 | 0.04 | -0.08 | 0.10 | 0.12 |
C18:3 | -0.43a | -0.36a | -0.19 | 0.20 | 0.19 |
C18:2 | -0.40a | -0.39a | -0.19 | 0.23 | 0.18 |
C18:1 | -0.33b | -0.32b | -0.15 | 0.15 | 0.13 |
C18 | -0.21 | -0.13 | -0.12 | 0.06 | 0.09 |
C18:3OH/C16:3Â DC | -0.29 | -0.06 | -0.02 | 0.18 | 0.18 |
C18:2OH/C16:2Â DC | -0.31b | -0.06 | -0.08 | 0.12 | 0.14 |
C18:1OH/C16:1Â DC | -0.22 | 0.02 | -0.04 | 0.06 | 0.07 |
C18OH/C16DC | -0.18 | 0.03 | -0.08 | -0.03 | 0.00 |
C20:4 | -0.28 | -0.30b | -0.12 | 0.26 | 0.27 |
C20:3 | -0.29b | -0.37a | -0.11 | 0.18 | 0.17 |
C20:2 | -0.25 | -0.20 | -0.14 | 0.11 | 0.14 |
C20:1 | -0.25 | -0.16 | -0.11 | 0.07 | 0.08 |
C20 | -0.18 | -0.04 | -0.09 | -0.02 | -0.01 |
C20:3OH/C18:3Â DC | 0.09 | 0.21 | -0.01 | -0.14 | -0.08 |
C20:2OH/C18:2Â DC | -0.16 | -0.15 | 0.06 | -0.14 | -0.14 |
C20:1OH/C18:1Â DC | -0.03 | 0.18 | -0.03 | 0.00 | 0.04 |
C20OHC18DC/C22:6 | -0.16 | 0.00 | -0.09 | -0.05 | -0.08 |
C22:5 | -0.28 | -0.20 | -0.14 | 0.15 | 0.09 |
C22:4 | -0.22 | -0.24 | -0.06 | 0.07 | 0.09 |
C22:3 | -0.03 | -0.11 | 0.01 | -0.06 | -0.03 |
C22:2 | 0.13 | -0.01 | -0.06 | 0.09 | 0.24 |
C22:1 | 0.06 | 0.01 | -0.12 | 0.28 | 0.36 |
C22 | -0.02 | -0.06 | 0.00 | 0.03 | 0.10 |