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Table 8 Relationships between rheumatoid arthritis clinical features and muscle metabolic intermediates

From: Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability

 

Disease activity

Disability

Pain

Exercise (min/d)

Physical activity (MET h/d)

Amino acids

     

Glycine

0.33b

0.50a

0.23

0.11

0.02

Alanine

-0.31b

0.03

-0.01

0.11

0.08

Serine

0.31b

0.20

0.17

-0.03

-0.01

Proline

0.20

0.36a

0.09

0.05

0.08

Valine

0.12

0.11

-0.04

0.05

-0.01

Leucine/isoleucine

0.09

0.18

-0.01

-0.08

-0.16

Methionine

0.07

0.16

-0.17

-0.01

-0.04

Histidine

-0.08

-0.02

-0.12

0.23

0.19

Phenylalanine

-0.06

-0.04

-0.21

0.06

0.04

Tyrosine

-0.06

0.08

-0.13

0.13

0.14

Aspartate/asparagine

0.34b

0.36a

0.20

-0.13

-0.12

Glutamate/glutamine

0.20

0.24

0.06

-0.12

-0.04

Ornithine

0.32b

0.39a

0.14

-0.21

-0.20

Citrulline

0.08

0.21

0.13

-0.02

0.13

Arginine

0.27

0.45a

0.24

-0.26

-0.27

Organic acids

     

Lactate

-0.09

-0.18

-0.06

-0.09

-0.12

Pyruvate

-0.22

-0.22

-0.21

0.16

0.05

Succinate

0.03

-0.01

0.15

-0.06

-0.12

Fumarate

-0.34b

-0.24

-0.15

0.05

-0.01

Malate

-0.28

-0.14

0.04

-0.01

-0.07

alphaKetoglutarate

-0.22

-0.03

-0.03

0.27

0.18

Citrate

0.17

0.23

0.29

0.05

0.14

Acylcarnitines

     

Free carnitine: C0

-0.10

0.19

0.10

0.04

0.08

C2

-0.07

0.08

0.07

-0.22

-0.02

C3

-0.05

0.10

-0.01

0.10

0.00

C4/Ci4

-0.02

-0.13

-0.20

0.09

0.16

C5:1

0.15

0.09

0.06

-0.10

0.05

C5

0.01

0.05

-0.24

0.14

0.10

C4OH

0.11

0.09

0.11

-0.11

-0.04

C6

0.05

-0.10

-0.24

0.30

0.29

C5OH

-0.24

0.04

0.14

0.14

0.25

C3DC

-0.17

0.13

0.03

-0.02

0.10

C4DC/Ci4DC

0.02

0.28b

0.05

-0.32b

-0.23

C8:1

-0.10

-0.05

-0.15

-0.07

0.00

C8

0.01

-0.11

-0.13

0.16

0.13

C5DC

0.19

0.20

0.03

-0.12

-0.11

C8:1OH/C6:1 DC

0.11

0.21

0.12

-0.05

-0.11

C6DC/C8OH

-0.02

0.03

-0.10

0.08

0.11

C10:3

0.02

0.15

0.15

-0.10

-0.09

C10:2

0.00

0.06

-0.05

-0.14

-0.20

C10:1

-0.09

-0.09

-0.08

0.19

0.11

C10

-0.05

-0.12

-0.13

0.15

0.14

C7DC

0.04

0.13

0.06

-0.20

-0.20

C8:1 DC

-0.17

-0.03

-0.13

-0.06

-0.09

C10OH:C8DC

-0.08

0.00

-0.15

0.06

0.07

C12:2

0.04

-0.01

-0.08

-0.24

-0.26

C12:1

-0.14

-0.12

-0.13

0.14

0.12

C12

-0.20

-0.22

-0.19

0.20

0.19

C12:2OH/C10:2 DC

-0.19

-0.03

-0.14

0.06

0.00

C12:1OH/C10:1 DC

-0.19

-0.07

-0.16

0.15

0.18

C12OH/C10DC

-0.16

0.03

-0.13

0.13

0.14

C14:3

-0.14

-0.09

-0.15

0.19

0.20

C14:2

-0.22

-0.17

-0.22

0.27

0.26

C14:1

-0.18

-0.16

-0.17

0.21

0.21

C14

-0.25

-0.21

-0.26

0.24

0.22

C14:3OH/C12:3 DC

-0.05

0.08

-0.01

-0.03

0.12

C14:2OH/C12:2 DC

-0.12

-0.03

-0.20

0.04

0.03

C14:1OH/C12:1 DC

-0.24

-0.11

-0.19

0.14

0.17

C14OH/C12DC

-0.13

0.03

-0.14

0.16

0.17

C16:3

-0.28

-0.19

-0.22

0.26

0.27

C16:2

-0.34b

-0.26

-0.26

0.35a

0.33b

C16:1

-0.28

-0.22

-0.17

0.22

0.18

C16

-0.27

-0.20

-0.19

0.17

0.18

C16:3OH/C14:3-DC

-0.16

-0.10

-0.03

0.11

0.19

C16:2OH/C14:2 DC

-0.26

-0.16

-0.19

0.12

0.10

C16:1OH/C14:1 DC

-0.25

-0.09

-0.21

0.10

0.12

C16OH/C14DC

-0.17

0.04

-0.08

0.10

0.12

C18:3

-0.43a

-0.36a

-0.19

0.20

0.19

C18:2

-0.40a

-0.39a

-0.19

0.23

0.18

C18:1

-0.33b

-0.32b

-0.15

0.15

0.13

C18

-0.21

-0.13

-0.12

0.06

0.09

C18:3OH/C16:3 DC

-0.29

-0.06

-0.02

0.18

0.18

C18:2OH/C16:2 DC

-0.31b

-0.06

-0.08

0.12

0.14

C18:1OH/C16:1 DC

-0.22

0.02

-0.04

0.06

0.07

C18OH/C16DC

-0.18

0.03

-0.08

-0.03

0.00

C20:4

-0.28

-0.30b

-0.12

0.26

0.27

C20:3

-0.29b

-0.37a

-0.11

0.18

0.17

C20:2

-0.25

-0.20

-0.14

0.11

0.14

C20:1

-0.25

-0.16

-0.11

0.07

0.08

C20

-0.18

-0.04

-0.09

-0.02

-0.01

C20:3OH/C18:3 DC

0.09

0.21

-0.01

-0.14

-0.08

C20:2OH/C18:2 DC

-0.16

-0.15

0.06

-0.14

-0.14

C20:1OH/C18:1 DC

-0.03

0.18

-0.03

0.00

0.04

C20OHC18DC/C22:6

-0.16

0.00

-0.09

-0.05

-0.08

C22:5

-0.28

-0.20

-0.14

0.15

0.09

C22:4

-0.22

-0.24

-0.06

0.07

0.09

C22:3

-0.03

-0.11

0.01

-0.06

-0.03

C22:2

0.13

-0.01

-0.06

0.09

0.24

C22:1

0.06

0.01

-0.12

0.28

0.36

C22

-0.02

-0.06

0.00

0.03

0.10

  1. Data are shown as Spearman correlation coefficients. aSignificant relationships (p < 0.05) to all red and green color and bSignificant relationships r ≥ |0.35| to all bright red and green