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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Semaphorin 7A as a potential immune regulator and promising therapeutic target in rheumatoid arthritis

Fig. 3

Semaphorin 7A (Sema7A) enhances expression of retinoic acid receptor-related orphan nuclear receptor γt (RORγt) and T-bet transcription factor in CD4+ T cells from healthy donors. Freshly isolated T cells (CD4+) were stimulated with 10 ng/ml of Sema7A or heat-denatured Sema7A (DSema7A) for 2 h. The expression of (a) T-bet and (b) RORγt was detected by immunoblotting. Bars show the mean ± SD of three independent experiments. **P < 0.01 versus unstimulated control or DSema7A. NC Negative control cells cultured in the absence of Sema7A

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Arthritis Research & Therapy

ISSN: 1478-6362

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