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Table 1 Muscle MRI scores and muscle parameters in ASS patients and controls

From: Comparative analyses of muscle MRI and muscular function in anti-synthetase syndrome patients and matched controls: a cross-sectional study

Muscle MRI scores ASS (N = 66) Controls (N = 67) p value
Total edema score (0–42)
  Edema extent score (0–18) 3.2 (5.3) 0.4 (1.4) <0.001
  Edema signal intensity score (0–18) 3.1 (5.0) 0.5 (1.7) <0.001
  Fascial edema score (0–6) 1.3 (2.1) 0.1 (0.4) <0.001
Total damage score (0–36)
  Fatty replacement score (0–30) 5.8 (4.3) 1.8 (2.4) <0.001
  Muscle volume reduction score (0–6) 0.6 (1.6) 0.1 (0.6) <0.036
Total MRI score (activity + damage; 0–78) 14.1 (14.1) 3.0 (4.2) <0.001
  Other muscle parameters
  Median CK, U/L (range) 95 (24–1344) 98 (35–839) <0.676
  CK > 2 × ULN, n/N (%) 4/67 (6) 1/65 (2) <0.366
  Median MMT14 score (25th, 75th centile) 139 (133, 140) 140 (138, 140) <0.001
  Median MMT4 score (25th, 75th centile) 40 (36, 40) 40 (39, 40) <0.004
  Median FI2 score (25th, 75th centile) 211 (116, 301) 324 (281, 330) <0.001
  1. Values presented as mean (SD) if not stated otherwise
  2. ASS anti-synthetase syndrome, CK creatinine kinase, ULN upper limit of normal, MMT4 manual muscle test of four muscles, MMT14 manual muscle test of 14 muscles, FI2 functional index, MRI magnetic resonance imaging