Skip to main content
Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis

Fig. 2

a A network derived from experimental data for immune cells containing corresponding input molecules for six genes, which were differentially expressed in whole blood RNA-sequencing (RNA-seq) data (Ingenuity Pathway Analysis (IPA)). b A network derived from experimental data with no tissue filter applied, containing corresponding input molecules for eight genes, which were differentially expressed in whole blood according to RNA-seq data. Coloured shapes represent genes previously associated with RA, which were also DE in RNA-seq data (input data) - expression log2 fold change is represented with colour intensity (red increased expression in patients with RA; blue decreased expression in patients with RA) and a corresponding value (RA patients versus healthy controls); white shapes represent interaction molecules; solid lines direct interaction evidence; broken lines indirect interaction evidence; *verified differentially expressed connector molecules, IPA

Back to article page