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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: α2AP regulates vascular alteration by inhibiting VEGF signaling in systemic sclerosis: the roles of α2AP in vascular dysfunction in systemic sclerosis

Fig. 2

Effect of blocking α2AP on vascular damage in a bleomycin-induced mouse model of systemic sclerosis. a The skin sections from mice treated with saline, bleomycin plus control IgG, or bleomycin plus α2AP-neutralizing antibodies were stained with antibodies to PECAM1. b The histogram shows quantitative representations of PECAM1 (n = 6). c Blood flow in the skin of mice treated with saline (n = 5), bleomycin plus control IgG (n = 4), or bleomycin plus α2AP-neutralizing antibodies (n = 4). The data represent the mean ± SEM. * P < 0.01. Scale bar, 200 μm

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