Identification of potential saliva and tear biomarkers in primary Sjögren’s syndrome, utilising the extraction of extracellular vesicles and proteomics analysis

Table 1 Clinical characteristics of patients with pSS included in the study

ID number	Age (years)	Anti-SSA^b	Anti-SSB^b	Schirmer test^c	Saliva secretion^d	Dry mouth	Dry eyes
PSS1	69	+	-	+	+	+	+
PSS2	41	+	+	-	+	+	+
pSS3	64	+	-	-	+	+	+
pSS4	33	+	-	+	+	+	-
pSS5	57	+	+	+	+	+	+
pSS6	55	+	+	+	+	+	+
pSS7	69	+	+	+	+	+	+
pSS8	40	+	+	+	+	+	+
pSS9	64	+	+	+	+	+	+
pSS10	72	+	+	+	+	+	+
pSS11	54	+	-	+	+	+	+
pSS12	36	+	-	+	+	+	+
pSS13	53	+	-	+	+	+	+
pSS14	47	+	+	+	+	+	+
pSS15	73	+	-	+	-	+	+
pSS16	54	+	+	+	+	+	+
pSS17	33	+	+	+	+	+	+
pSS18	69	+	+	+	+	+	+
pSS19	51	+	-	+	-	+	+
pSS20	48	+	+	+	+	+	+
pSS21^a	48	+	+	+	+	+	+
pSS22^a	44	+	+	+	+	+	+
pSS23^a	40	+	+	+	+	+	+
pSS24^a	47	+	+	+	+	+	+
pSS25^a	64	+	+	+	+	+	+
pSS26^a	39	+	+	+	+	+	+
pSS27^a	51	+	+	+	+	+	+

^aPatients with pSS included in pooled tear sample only. ^bAutoantibody production was assessed by ELISA. ^cValues are in mm/5 minutes; normal flow >5 mm/5 minutes. The + symbol indicates dryness and tear secretion <5 mm/5 minutes. ^dValues are in ml/15 minutes; normal flow >1.5 ml/15. The + symbol indicates dryness and stimulated whole saliva secretion <3.5 ml/5 minutes

ISSN: 1478-6362