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Table 3 Highly upregulated proteins in stimulated whole saliva from patients with pSS

From: Identification of potential saliva and tear biomarkers in primary Sjögren’s syndrome, utilising the extraction of extracellular vesicles and proteomics analysis

Number Gene Related proteina Replicates (pSS : C) Spectral counts (pSS : C) Classification and functionb
1 LCN2 Neutrophil gelatinase-associated lipocalin 10 : 2 38 : 2 Iron-binding protein; innate immunity (neutrophils)
2 GRN Granulins 7 : 0 12 : 0 Cytokine-like peptide; inflammation, wound repair, tissue remodelling
3 CALM Calmodulin 7 : 1 17 : 1 Calcium-binding protein; intracellular signalling
4 NPC2 Epididymal secretory protein 1 6 : 0 11 : 0 Cholesterol transporter; cholesterol homeostasis (endosome/lysosome)
5 CALML5 Calmodulin-like protein 5 5 : 0 13 : 0 Calcium-binding protein; differentiation of keratinocytes
  1. aThe five most upregulated proteins in whole saliva from patients with primary Sjögren’s syndrome (pSS) deviating in replicates, i.e. number of individuals (frequency), and spectral counts, as identified by proteomics analysis and Scaffold (v 4.4.6, http://www.proteomesoftware.com/products/scaffold/). bThe classification and functions of the proteins presented were identified using publicly available databases, such as UniProt (http://www.uniprot.org). C controls