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Table 4 Highly upregulated proteins in EVs isolated from stimulated whole saliva from patients with pSS

From: Identification of potential saliva and tear biomarkers in primary Sjögren’s syndrome, utilising the extraction of extracellular vesicles and proteomics analysis

Number Gene Related proteina Replicates (pSS : C) Spectral counts (pSS : C) Classification and functionb
1 APMAP Adipocyte plasma membrane-associated protein 7 : 0 26 : 0 Enzyme; adipocyte differentiation
2 GNA13 Guanine nucleotide-binding protein subunit alpha-13 6 : 0 11 : 0 G-protein; transmembrane signalling
3 WDR1 WD repeat-containing protein 1 6 : 0 11 : 0 Regulatory protein; disassembly of actin filaments
4 SIRPA Tyrosine-protein phosphatase non-receptor type substrate 1 (PTPN1) 6 : 0 9 : 0 Glycoprotein; innate immunity (NK cells), dendritic cell inhibition
5 LSP1 Lymphocyte-specific protein 1 5 : 0 9 : 0 Actin-binding protein; neutrophil activation, chemotaxis
  1. aThe five most upregulated proteins in extracellular vesicles isolated from whole saliva from patients with primary Sjögren’s syndrome (pSS) deviating in replicates, i.e. number of individuals (frequency), and spectral counts, as identified by proteomics analysis and Scaffold (v 4.4.6, http://www.proteomesoftware.com/products/scaffold/). bClassification and functions of the proteins presented were identified using publicly available databases, such as UniProt (http://www.uniprot.org). C controls, NK natural killer