Skip to main content

Table 5 Highly upregulated proteins in tear fluid from patients with pSS

From: Identification of potential saliva and tear biomarkers in primary Sjögren’s syndrome, utilising the extraction of extracellular vesicles and proteomics analysis

Number

Gene

Related proteina

Replicates (pSS : C)

Spectral counts (pSS : C)

Classification and functionb

1

APEX1

DNA-(apurinic or apyrimidinic site) lyase

10 : 1

22 : 1

Enzyme; oxidative stress, DNA repair, regulation of transcriptional factors

2

PRDX3

Thioredoxin-dependent peroxidase reductase

8 : 0

15 : 0

Enzyme; redox regulation, regulates NF-kappa-B activation (B cell survival)

3

CPNE1

Copine 1

9 : 2

23 : 2

Phospholipid-binding protein (calcium-dependent), TNF-α receptor signalling

4

ACO2

Aconitate hydratase

7 :0

19 : 0

Enzyme; tricarboxylic acid cycle/Krebs cycle, carbohydrate metabolism

5

LMO7

LIM domain only protein 7

7 : 0

9 : 0

Cell signalling, cell adhesion, ubiquitination

  1. aThe five most upregulated proteins in tear fluid from patients with primary Sjögren’s syndrome (pSS) deviating in replicates, i.e. number of individuals (frequency), and spectral counts, as identified by proteomics analysis and Scaffold (v 4.4.6, http://www.proteomesoftware.com/products/scaffold/). bClassification and functions of the proteins presented were identified using publicly available databases, such as UniProt (http://www.uniprot.org) C controls