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Table 5 Highly upregulated proteins in tear fluid from patients with pSS

From: Identification of potential saliva and tear biomarkers in primary Sjögren’s syndrome, utilising the extraction of extracellular vesicles and proteomics analysis

Number Gene Related proteina Replicates (pSS : C) Spectral counts (pSS : C) Classification and functionb
1 APEX1 DNA-(apurinic or apyrimidinic site) lyase 10 : 1 22 : 1 Enzyme; oxidative stress, DNA repair, regulation of transcriptional factors
2 PRDX3 Thioredoxin-dependent peroxidase reductase 8 : 0 15 : 0 Enzyme; redox regulation, regulates NF-kappa-B activation (B cell survival)
3 CPNE1 Copine 1 9 : 2 23 : 2 Phospholipid-binding protein (calcium-dependent), TNF-α receptor signalling
4 ACO2 Aconitate hydratase 7 :0 19 : 0 Enzyme; tricarboxylic acid cycle/Krebs cycle, carbohydrate metabolism
5 LMO7 LIM domain only protein 7 7 : 0 9 : 0 Cell signalling, cell adhesion, ubiquitination
  1. aThe five most upregulated proteins in tear fluid from patients with primary Sjögren’s syndrome (pSS) deviating in replicates, i.e. number of individuals (frequency), and spectral counts, as identified by proteomics analysis and Scaffold (v 4.4.6, http://www.proteomesoftware.com/products/scaffold/). bClassification and functions of the proteins presented were identified using publicly available databases, such as UniProt (http://www.uniprot.org) C controls