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Fig. 7 | Arthritis Research & Therapy

Fig. 7

From: Circulating plasmablasts/plasma cells: a potential biomarker for IgG4-related disease

Fig. 7

The secretion of immunoglobulin by regulatory B cells (Bregs), CD19+C24CD38hi plasmablasts/plasma cells, memory B cells, and naïve B cells. B-cell subsets, including CD19+CD24CD38hi plasmablasts/plasma cells, Bregs, memory B cells, and naïve B cells from peripheral blood of patients with immunoglobulin G4-related disease (IgG4-RD) were sorted by flow cytometry and underwent cell culture in vitro. After 7 days of cell culture with CD40L and CpG ODN 2006, the supernatants were collected, and immunoglobulin secretion was analyzed. Horizontal histogram illustrates (a) IgG4, (b) IgG, (c) IgE, and (d) IgM secreted by four subsets of B cells. Columns AD represent Bregs, CD19+C24CD38hi plasmablasts/plasma cells, memory B cells, and naïve B cells, respectively. e Flow diagram of a representative patient with IgG4-RD. (*: P <0.05, **: P <0.01, ***: P <0.001)

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