Table 3 Genes downregulated in CD19+CD24−CD38hi plasmablasts/plasma cells of patients with immunoglobulin G4-related disease
From: Circulating plasmablasts/plasma cells: a potential biomarker for IgG4-related disease
Gene symbol | Fold change | Function |
|---|---|---|
TRF8 | –7.34056 | Transcription factor |
SPIB | –4.91502 | Transcription factor |
PAX5 | –7.43584 | Transcription factor |
FOXO1 | –3.15445 | Transcription factor, anti-apoptosis |
STAT6 | –3.06941 | Transcription factor, signal transduction |
CD72 | –17.9585 | Cell surface, intracellular signaling |
CD37 | –9.23361 | Cell surface, intracellular signaling |
CD40 | –4.37638 | Cell surface, signal transduction |
CD24 | –22.3673 | Cell surface, intracellular signaling |
CD1C | –3.49943 | Cell surface |
CD19 | –2.03392 | Cell surface, signal transduction |
SELL | –2.59485 | Cell surface, adhesion receptors |
CD22 | –8.40913 | Cell surface, intracellular signaling |
CXCR4 | –5.3050 | Chemokine receptor |
CXCR5 | –11.9723 | Chemokine receptor |
CCR6 | –20.5228 | Chemokine receptor |
CCR7 | –9.86589 | Chemokine receptor |
TNFSF12 TNFSF12-TNFSF13 | –2.22538 | Signal transduction |
VAV3 | –10.284 | Signal transduction |
IL6 | –5.19 | Cytokine |
IL7 | –9.61703 | Cytokine |
HLA-DRA | –3.2849 | Peptide antigen binding |
BCR | –7.43584 | Kinase activity, protein binding |
HLA-DRB1 | –4.292155 | Peptide antigen binding |
FYN | –2.82807 | Tyrosine kinase |
BLK | –6.10205 | Tyrosine kinase |
BCL11A | –14.6221 | Transcriptional regulation activity |
BACH2 | –14.6267 | Transcriptional regulation activity |
ID3 | –2.80866 | Transcriptional regulation activity |
CIITA | –4.67153 | HIA class II complex, transcription coactivator |
IGF1R | –5.53806 | Inhibitor of apoptosis |
ITGB2 | –2.37331 | Integrin |