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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Proangiogenic effects of soluble α-Klotho on systemic sclerosis dermal microvascular endothelial cells

Fig. 5

Decreased expression of α-Klotho in the skin of patients with systemic sclerosis (SSc). a Representative microphotographs of skin sections from healthy controls and patients with SSc immunostained with rabbit monoclonal anti-human α-Klotho antibody and counterstained with hematoxylin. Boxed area (upper panels) is shown at higher magnification in the respective lower panels. α-Klotho immunostaining is decreased in dermal microvessels of the skin in SSc compared with healthy control skin. Scale bar 100 μm (upper panels) and 20 μm (lower panels). b Semi-quantitative analysis of α-Klotho immunostaining in dermal microvessels. Data are mean ± SEM of immunostaining score performed on skin sections from eight patients with SSc and eight healthy controls. Student’s t test was used for statistical analysis; the p value is indicated

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