Fig. 1
From: Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis
LAP is a potent inhibitor of DHODH activity. a Synthetic strategy for developing LAP sodium salt from lawsone. b The top-ranked GOLD solution for LAP is shown inside the hDHODH active site, in hydrophobic and polar contacts with selected residues of the enzyme. Hydrogen bonds are here represented by dashed magenta lines. c Inhibitory effect of LAP on human dihydroorotate dehydrogenase (hDHODH). Half maximal inhibitory concentration (IC 50 ) determination of LAP based on DCIP colorimetric assay