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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Epstein-Barr virus lytic infection promotes activation of Toll-like receptor 8 innate immune response in systemic sclerosis monocytes

Fig. 5

CL075/TLR8 synthetic agonist ligand, IFNγ, and TNFα induce TLR8 expression. Cellular lysates from THP-1 cells treated with TLR synthetic ligand: a CL264 (adenine analog), R837 (Imiquimod), CL075 (3 M002), or b IFNβ, IFNγ, and TNFα or untreated were extracted after 24 h and analyzed by Western blot. Representative immunoblots of TLR8 and IRF7 expression in whole cell lysates. β-actin was used as loading control. IFN interferon, TNF tumor necrosis factor; TLR Toll-like receptor

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