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Table 2 EBV gene expression and DNA in circulating monocytes and in skin macrophages of dcSSc patients

From: Epstein-Barr virus lytic infection promotes activation of Toll-like receptor 8 innate immune response in systemic sclerosis monocytes

EBV protein/DNA Number of dcSSc patients positive/tested Number of HDs positive/tested
BFRF1* (monocytes) 3/8 0/6
BFLF2* (monocytes) 4/8 0/6
EBER1 DNA** (monocytes) 8/8 3/6
EBER1 DNA** (B-lymphocytes) 8/8 8/8
BZLF1/Zebra monocytes mRNA *** 4/8 0/6
CD163+/macrophages*** 6/18 0/8
  1. *Tested by Western blot
  2. **Tested by real-time polymerase chain reaction
  3. ***Tested by immunohistochemistry on skin sections
  4. dcSSc diffuse cutaneous systemic sclerosis, EBV Epstein-Barr virus, HD healthy donor