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Table 2 EBV gene expression and DNA in circulating monocytes and in skin macrophages of dcSSc patients

From: Epstein-Barr virus lytic infection promotes activation of Toll-like receptor 8 innate immune response in systemic sclerosis monocytes

EBV protein/DNA

Number of dcSSc patients positive/tested

Number of HDs positive/tested

BFRF1* (monocytes)

3/8

0/6

BFLF2* (monocytes)

4/8

0/6

EBER1 DNA** (monocytes)

8/8

3/6

EBER1 DNA** (B-lymphocytes)

8/8

8/8

BZLF1/Zebra monocytes mRNA ***

4/8

0/6

CD163+/macrophages***

6/18

0/8

  1. *Tested by Western blot
  2. **Tested by real-time polymerase chain reaction
  3. ***Tested by immunohistochemistry on skin sections
  4. dcSSc diffuse cutaneous systemic sclerosis, EBV Epstein-Barr virus, HD healthy donor