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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Excessive activation of the TLR9/TGF-β1/PDGF-B pathway in the peripheral blood of patients with systemic lupus erythematosus

Fig. 4

CpG induces upregulation of transforming growth factor-β1 (TGF-β1) and platelet-derived growth factor-B (PDGF-B) in vitro. Blood cells from healthy controls (a,b; N Control = 12) and systemic lupus erythematosus (SLE) patients (c,d; N SLE = 16) were stimulated with or without 500 nM CpG for 24 h, and then the mRNA expression of TGF-β1 and PDGF-B were detected by qPCR. Multiple rates of mRNA expression of TGF-β1 (e) and PDGF-B (f) in healthy controls (N Control = 12) and SLE patients (N SLE = 16) were calculated as CpG/Media. The results were presented as mean and SEM. GAPDH glyceraldehyde-3-phosphate dehydrogenase

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Arthritis Research & Therapy

ISSN: 1478-6362

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