Table 3 Multivariate Cox regression analysis for ECG-4 and ECG-5

Age at each visit

1.05 (1.01–1.07)

0.002

1.04 (1.007–1.06)

0.01

AMS (2 years prior to ECG)

1.08 (1.02–1.16)

0.009

1.07 (1.002–1.14)

0.04

SDI

1.29 (1.10–1.53)

0.002

1.28 (1.08–1.51)

0.004

Hyperlipidemia on statins ever before ECG

0.44 (0.21–0.89)

0.02

0.44 (0.22–0.87)

0.02

Hypertension

0.66 (0.34–1.26)

0.21

0.75 (0.4–1.39)

0.36

Ever smoked before ECG

1.13 (0.59–2.16)

0.71

1.09 (0.58–2.06)

0.77

Immunosuppressive treatment at each visit

1.88 (1.01–3.51)

0.05

1.67 (0.93–3.04)

0.09

Antimalarial treatment at each visit

1.76 (0.87–3.58)

0.12

1.81 (0.92–3.56)

0.12