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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Presence of an interferon signature in individuals who are anti-nuclear antibody positive lacking a systemic autoimmune rheumatic disease diagnosis

Fig. 3

Association between the number of different anti-nuclear antibody (ANA) specificities detected and interferon (IFN)-induced gene expression. a The number of different ANA specificities detected using the BioPlex® 2200 system in asymptomatic ANA+ individuals, participants with undifferentiated connective tissue disease (UCTD), and participants with early systemic autoimmune rheumatic disease (SARD). Significant differences from patients with early SARD are indicated as * p < 0.05, *** p < 0.001. Association between IFN5 score and the number of autoantibodies detected in (b) non-SARD (asymptomatic ANA+ and UCTD) and early SARD participants and in (c) asymptomatic ANA+ individuals and participants with UCTD. Significant associations are indicated

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