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Table 2 Initial lymphocyte subpopulations levels in patients with RA and controls

From: Th17 and CD24hiCD27+ regulatory B lymphocytes are biomarkers of response to biologics in rheumatoid arthritis

Lymphocyte populations

Patient group (n = 31)

Control group (n = 17)

p

Lymphocytes

 (%)

23.8 (17.0–30.0)

18.6 (13.6–28.5)

0.413

 (/mm3)

1600 (1300–2000)

1700 (1050–1950)

0.974

B lymphocytes

 (%)

11.1 (8.2–17.6)

10.0 (7.3–14.4)

0.651

 (/mm3)

156 (95–278)

151 (122–195)

0.957

TCD4+

 (%)

53.5 (47.0–60.9)

51.7 (44.8–58.1)

0.779

 (/mm3)

723 (569–1081)

739 (549–955)

0.821

T2/Breg

 (%)

8.5 (5.9–10.5)

13.8 (10.9–15.6)

<0.001**

 (/mm3)

13 (9–22)

17 (14–31)

0.014*

CD24hiCD27+ Breg

 (%)

16.3 (13.1–28.6)

18.8 (11.9–24.5)

0.612

 (/mm3)

33 (20–45)

23 (19–34)

0.185

Treg

 (%)

6.4 (4.9–8.1)

7.1 (6.3–8.3)

0.223

 (/mm3)

49 (35–65)

56 (44–68)

0.371

Th17

 (%)

19.6 (13.2–22.7)

23.4 (18.6–28.4)

0.036*

 (/mm)

77 (45–97)

76 (51–135)

0.539

  1. Total lymphocytes, B lymphocytes, T2/B regulatory cells (Breg), CD24hiCD27+ Breg, T regulatory cells (Treg) and T helper 17 (Th17) observed in patients with rheumatoid arthritis (RA) and controls in absolute value (cells per mm3) and percentage; expressed in median and IQR; difference observed between the two groups as per the Mann–Whitney test. *p < 0.05. **p < 0.001