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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Multiplex serum protein analysis reveals potential mechanisms and markers of response to hyperimmune caprine serum in systemic sclerosis

Fig. 1

Change in modified Rodnan skin score after 26 weeks of treatment with hyperimmune caprine serum compared with placebo or no treatment. In the extended clinical trial dataset patients received 26 weeks of therapy with HICS or placebo. Seven subjects that had received placebo were then treated with HICS. For all subjects there was a 52-week visit and so MRSS between 26 and 52 weeks was available for placebo-treated cases, providing an extended dataset of 17 subjects receiving HICS and 13 with no active treatment. Treatment blind for the first 26 weeks was maintained to week 52. There was statistically significant difference between these two treatment groups. These data extended the dataset from the placebo-controlled phase of the study that had demonstrated a trend of improvement for MRSS and for responder frequency defined by improvement of at least four skin score units and 20% of baseline MRSS. The placebo-controlled phase has been previously described [11]. HICS hyperimmune caprine serum, MRSS modified Rodnan skin score

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