Fig. 2

Unsupervised hierarchical cluster analysis for multiplex serum proteins at baseline and 26 weeks during the placebo-controlled trial of HICS. Unsupervised cluster analysis was undertaken to identify any subgroups within the study cohort at baseline based upon the serum levels of multiple protein analytes as described in text. The same analysis was repeated for serum samples after 26 weeks of treatment with HICS or placebo. The randomly assigned treatment allocation is shown for each subject. Data for baseline samples are shown in panel a. After 26 weeks of treatment there were clear changes in the patterns of protein analytes that were spread between the two treatment arms as shown in panel b. HICS hyperimmune caprine serum