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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Multiplex serum protein analysis reveals potential mechanisms and markers of response to hyperimmune caprine serum in systemic sclerosis

Fig. 3

Supervised analysis for change in serum proteins according to treatment or responder status in the 26-week placebo-controlled trial of HICS. a Cluster analysis was undertaken for serum analytes after allocation to HICS or placebo during the 26-week parallel-group controlled phase of the clinical trial to identify any subgroups within the study cohort at baseline based upon the serum levels of multiple protein analytes as described in text. A pattern of upregulation or downregulation of specific proteins is seen more frequently in cases treated with HICS than controls. b The same analysis was repeated with subjects allocated to responder or non-responder categories based upon improvement in MRSS by at least four skin score units and 20% of baseline MRSS. Of the responders 5/6 were in the HICS-treated arm of the study. In this way groups of proteins that are clustered for similar patterns of change in response to HICS or associated with clinically meaningful improvement in MRSS

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