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Table 1 HLA-DRβ1 categorized according to 3rd HVR sequences, DRB1 alleles encoding each sequence, and associated charges

From: Characterization of the HLA-DRβ1 third hypervariable region amino acid sequence according to charge and parental inheritance in systemic sclerosis

3rd HVR aa 67–74 DRB1 alleles Charge
1 LLEQRRAA 01:01, 01:02, 01:08, 04:04, 04:05, 04:08, 14:02, 14:06, 14:20 +1
2 I--DE--- 01:03, 04:02, 11:02, 13:01, 13:02, 13:04, 13:28 −2
3 ---R---- 10:01 +2
4 I---A--- 15:01, 15:02, 15:03 0
5 F--D---- 11:01, 11:04, 12:02, 13:05, 16:01 0
6 ---D---- 16:02 0
7 ----K--- 04:01 +1
8 -------E 04:03, 04:07 0
9 I--D--GQ 07:01 0
10 F--R---E 09:01 +1
11 F--D---L 08:01, 08:02, 08:04, 08:06 0
12 I--D---L 08:03 0
13 F--DE--- 11:03 −2
14 I--D---- 12:01 0
15 ----K-GR 03:01 +2
16 I--DK--- 13:03 0
17 ---R---E 14:01 +1
  1. Summary is for all 3rd HVR sequences and DRB1 alleles observed in at least one study subject
  2. 3rd HVR third hypervariable region, aa amino acids