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Table 1 HLA-DRβ1 categorized according to 3rd HVR sequences, DRB1 alleles encoding each sequence, and associated charges

From: Characterization of the HLA-DRβ1 third hypervariable region amino acid sequence according to charge and parental inheritance in systemic sclerosis

3rd HVR

aa 67–74

DRB1 alleles

Charge

1

LLEQRRAA

01:01, 01:02, 01:08, 04:04, 04:05, 04:08, 14:02, 14:06, 14:20

+1

2

I--DE---

01:03, 04:02, 11:02, 13:01, 13:02, 13:04, 13:28

−2

3

---R----

10:01

+2

4

I---A---

15:01, 15:02, 15:03

0

5

F--D----

11:01, 11:04, 12:02, 13:05, 16:01

0

6

---D----

16:02

0

7

----K---

04:01

+1

8

-------E

04:03, 04:07

0

9

I--D--GQ

07:01

0

10

F--R---E

09:01

+1

11

F--D---L

08:01, 08:02, 08:04, 08:06

0

12

I--D---L

08:03

0

13

F--DE---

11:03

−2

14

I--D----

12:01

0

15

----K-GR

03:01

+2

16

I--DK---

13:03

0

17

---R---E

14:01

+1

  1. Summary is for all 3rd HVR sequences and DRB1 alleles observed in at least one study subject
  2. 3rd HVR third hypervariable region, aa amino acids