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Table 2 Allele frequencies classified according to the third hypervariable region in controls and SSc patients

From: Characterization of the HLA-DRβ1 third hypervariable region amino acid sequence according to charge and parental inheritance in systemic sclerosis

  Controls SSc   
HVR region n (%) n (%) p value OR (95% CI)
1 68 (18.4) 34 (14.0) 0.160 0.73 (0.46–1.14)
2 44 (11.9) 24 (9.9) 0.447 0.82 (0.48–1.38)
3 3 (0.8) 1 (0.4)   
4 58 (15.7) 21 (8.7) 0.012 0.51 (0.30–0.87)
5 36 (9.7) 43 (17.8) 0.004§ 2.00 (1.25–3.23)
6 0 (0.0) 1 (0.4)   –
7 34 (9.2) 25 (10.3) 0.640 1.14 (0.66–1.96)
8 4 (1.1) 8 (3.3)   
9 48 (13.0) 29 (12.0) 0.718 0.91 (0.56–1.49)
10 4 (1.1) 2 (0.8)   
11 8 (2.1) 16 (6.6) 0.006# 3.20 (1.35–7.61)
12 1 (0.3) 0 (0.0)   –
13 5 (1.3) 6 (2.5)   
14 6 (1.6) 4 (1.7)   
15 41 (11.1) 26 (10.7) 0.896 0.97 (0.57–1.63)
16 3 (0.8) 0 (0.0)   –
17 7 (1.9) 2 (0.8)   
All 370 242   
  1. Third HVR overall distribution, SSc patients versus controls, p = 0.007
  2. § p c = 0.032
  3. # p c = 0.048
  4. SSc systemic sclerosis, HVR hypervariable region, OR odds ratio, CI confidence interval, p c p value corrected for multiple comparisons
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Arthritis Research & Therapy

ISSN: 1478-6362

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