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Table 3 DQβ1 hypervariable region and charge, amino acids 70–77a

From: Characterization of the HLA-DRβ1 third hypervariable region amino acid sequence according to charge and parental inheritance in systemic sclerosis

  Amino acid position Overall charge
Allele 70 71 72 73 74 75 76 77  
05:01/2/3 G A R A S V D R +1
06:01/4/9/11, 03:01/2/3 R T E T 0
06:02/3/11/16 T E L T −1
02:01/2 R K A +3b
04:01/2 E D T −2
  1. aAmino acids that differ from the consensus (alleles on the first line) by charge are presented in bold. Sequences encoded by uncommon alleles not present in our study populations are not included
  2. bAmong SSc patients with DQβ1 + 3 charge, eight were inherited paternally and 31 inherited maternally (p corrected = 0.001)