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Table 4 DQα1 hypervariable region and charge, amino acids 47–56a

From: Characterization of the HLA-DRβ1 third hypervariable region amino acid sequence according to charge and parental inheritance in systemic sclerosis

 

Amino acid position

Overall chargeb

Allele

47

48

49

50

51

52

53

54

55

56

 

01:01/2/3/4/5

R

W

P

E

F

S

K

F

G

G

+1

02:01

K

L

H

R

R

+4

03:01/2/3

Q

L

R

R

R

R

+4

04:01

C

V

R

Q

R

+2

05:01/3/5

C

V

R

Q

R

+2

06:01

C

V

R

Q

R

+2

  1. aAmino acids that differ from the consensus (alleles on the first line) by charge are presented in bold. Sequences encoded by uncommon alleles not present in our study populations are not included
  2. bParental inheritance was not skewed according to any DQα1 charge category. Similarly, results were not skewed if alternatively considered to extend to include a polymorphism at DQα1 amino acid 64