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Table 4 DQα1 hypervariable region and charge, amino acids 47–56a

From: Characterization of the HLA-DRβ1 third hypervariable region amino acid sequence according to charge and parental inheritance in systemic sclerosis

  Amino acid position Overall chargeb
Allele 47 48 49 50 51 52 53 54 55 56  
01:01/2/3/4/5 R W P E F S K F G G +1
02:01 K L H R R +4
03:01/2/3 Q L R R R R +4
04:01 C V R Q R +2
05:01/3/5 C V R Q R +2
06:01 C V R Q R +2
  1. aAmino acids that differ from the consensus (alleles on the first line) by charge are presented in bold. Sequences encoded by uncommon alleles not present in our study populations are not included
  2. bParental inheritance was not skewed according to any DQα1 charge category. Similarly, results were not skewed if alternatively considered to extend to include a polymorphism at DQα1 amino acid 64