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Table 4 ABCG2 analysis according to ancestry, with adjustment for potential confounders

From: Population-specific association between ABCG2 variants and tophaceous disease in people with gout

ABCG2 variant Risk allele   All participants (n = 1778) Non-Polynesian ancestry (n = 927) Māori or Pacific ancestry (n = 851) Eastern Polynesian ancestry (n = 464) Western Polynesian ancestry (n = 387)
Allelic OR (95% CI) P Allelic OR (95% CI) P Allelic OR (95% CI) P Allelic OR (95% CI) P Allelic OR (95% CI) P
rs2231142 T Unadjusted 1.24 (1.02–1.51) 0.033 0.97 (0.73–1.28) 0.80 1.50 (1.14–1.99) 0.004 1.28 (0.84–1.96) 0.25 1.71 (1.07–2.72) 0.017
   Adjusted for age, sex, ancestrya 1.30 (1.06–1.58) 0.012 0.99 (0.74–1.31) 0.93 1.51 (1.14–2.01) 0.004 1.24 (0.81–1.91) 0.32 1.79 (1.12–2.87) 0.015
   Adjusted for age, sex, ancestrya, highest recorded urate, serum creatinine and disease duration 1.16 (0.94–1.43) 0.17 0.97 (0.72–1.30) 0.83 1.37 (1.01–1.85) 0.042 0.91 (0.57–1.45) 0.70 1.66 (1.01–2.75) 0.048
rs10011796 T Unadjusted 1.33 (1.01–1.74) 0.040 1.16 (0.81–1.66) 0.41 1.44 (0.94–2.20) 0.093 0.87 (0.52–1.46) 0.60 3.76 (1.61–8.77) 0.002
   Adjusted for age, sex, ancestrya 1.31 (0.997–1.72) 0.052 1.18 (0.83–1.69) 0.36 1.45 (0.95–2.22) 0.089 0.87 (0.52–1.47) 0.61 3.75 (1.60–8.77) 0.002
   Adjusted for age, sex, ancestrya, highest recorded urate, serum creatinine and disease duration 1.25 (0.94–1.65) 0.13 1.12 (0.77–1.62) 0.55 1.39 (0.88–2.18) 0.16 0.82 (0.47–1.43) 0.49 3.23 (1.35–7.76) 0.009
  1. aAdjusted by ancestry for analysis in “All participants”