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Table 2 Patient characteristics at week 52 by low disease activity at week 208 in the adalimumab discontinuation groupa

From: Low disease activity for up to 3 years after adalimumab discontinuation in patients with early rheumatoid arthritis: 2-year results of the HOPEFUL-3 Study

 

LDA at week 208 (n = 59)

Failed LDA at week 208 (n = 15)

p Value b

Mean

SD

Mean

SD

Female sex, n (%)

49

83.1

12

80.0

1.0000

Age, years

54.1

11.5

55.8

15.9

0.4675

Disease duration, years

1.3

0.3

1.2

0.3

0.4079

MTX dose, mg/week

7.3

2.0

6.5

1.6

0.2432

Steroid use, n (%)

14

23.7

3

20.0

1.0000

TJC28

0.9

2.0

1.3

1.9

0.2210

SJC28

0.4

0.9

0.4

0.9

0.9329

CRP, mg/dl

0.1

0.2

0.2

0.1

0.0026c

ESR, mm/h

16.4

11.2

25.9

16.7

0.0154d

EGA

7.2

6.9

9.1

8.0

0.4145

PGA

7.2

8.4

13.5

17.5

0.1600

Pain VAS

7.5

7.8

12.6

17.2

0.3242

DAS28-ESR

2.3

0.7

2.8

0.9

0.0113d

DAS28-CRP

1.7

0.6

2.0

0.7

0.0715

HAQ

0.197

0.298

0.208

0.330

0.9240

Erosion

6.5

5.4

9.7

18.9

0.7467

JSN

6.3

9.1

8.3

23.5

0.1199

mTSS

12.8

12.8

18.0

42.2

0.2390

MMP-3, ng/ml

59.0

47.4

67.8

51.9

0.2475

RF

32.3

33.0

83.1

85.3

0.0077c

ACPA, U/ml

113.4

237.9

620.5

1334.9

0.0113d

  1. Abbreviations: ADA Adalimumab, LDA Low disease activity, MTX Methotrexate, TJC Tender joint count, SJC Swollen joint count, CRP C-reactive protein, ESR Erythrocyte sedimentation rate, EGA Evaluator global assessment, PGA Patient global assessment, VAS Visual analogue scale, DAS28 28-joint Disease Activity Score, HAQ Health Assessment Questionnaire, JSN Joint space narrowing, mTSS Modified total Sharp score, MMP-3 Matrix metalloproteinase 3, RF Rheumatoid factor, ACPA Anti-cyclic citrullinated peptide antibody
  2. a Values are expressed as mean ± SD, unless otherwise indicated
  3. b Statistical significance assessed by Fisher’s exact test for categorical data and the Wilcoxon rank sum test for continuous data
  4. c p < 0.01 LDA vs. failed LDA at week 208
  5. d p < 0.05 LDA vs. failed LDA at week 208