Poor prognostic factor | Outcome | Study type | References |
---|---|---|---|
Increased DAS28 or single components | Radiographic progression Absence of remission | RCT, cohort Cohort | |
Increased MBDA | Radiographic progression | RCT, cohort | |
Presence or high titers of RF and/or ACPA | Radiographic progression Absence of remission | RCT, cohort Cohort | [42] |
Presence of erosions | Radiographic progression | RCT, cohort | |
Increased HAQ | Absence of remission Functional limitation | Cohort RCT | [13] |
Smoking | Radiographic progression | RCT | [15] |
Delayed diagnosis/treatment initiation | Absence of remission | Cohort | [16] |
Ultrasound Doppler activity | Radiographic progression Absence of remission | Cohort | |
MRI bone edema | Radiographic progression | RCT, cohort | |
Genetic predisposition (relatedness) | Radiographic damage | Cohort | [29] |