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Table 2 Flares and medical treatments during pregnancy in patients with and without tumor necrosis factor inhibitor use until early pregnancy
| RA | axSpA | |||
|---|---|---|---|---|
| TNFi until positive pregnancy testa (n = 15) | TNFi-negative (n = 60) | TNFi until positive pregnancy test (n = 24) | TNFi-negative (n = 37) | |
| Patients (n) with flare at | ||||
| First trimester | 6 | 4 | 1 | 2 |
| Second trimester | 3 | 4 | 5 | 1 |
| Third trimester | 1 | 4 | 4 | 2 |
| Medication at conception | ||||
| TNFi | 15 (100) | 0 (0) | 24 (100) | 0 (0) |
| NSAIDs | 1 (6.7) | 13 (21.7) | 11 (45.8) | 23 (61.2) |
| Glucocorticosteroidsb | 1 (6.7) | 23 (38.3) | 2 (8.3) | 1(3.7) |
| DMARDs | 2 (13.3) | 27 (45) | 3 (12.5) | 2 (5.4) |
| SSZ | 1 (6.7) | 17(28.3) | 3 (12.5) | 2 (5.4) |
| HCQ | 1 (6.7) | 7 (11.7) | ||
| SSZ and HCQ | 3 (5) | |||
| Medication during pregnancy | ||||
| TNFi | 4 (26.7) | 5 (8.3) | 10 (41.7) | 1 (2.7) |
| NSAIDs | 5 (33.3) | 23 (38.3) | 15 (62.5) | 27 (73) |
| Glucocorticosteroidsb | 7 (46.7) | 29 (48.3) | 12 (50.0) | 3 (8.1) |
| DMARDs | 7 (46.7) | 38 (63.3) | 3 (12.5) | 2 (5.4) |
| SSZ | 1 (6.7) | 23 (38.3) | 3 (12.5) | 2 (5.4) |
| HCQ | 1 (6.7) | 9 (15) | ||
| SSZ and HCQ | 5 (33.3) | 6 (10) | ||
| Initiation of medication during pregnancy | 9 (60) | 16 (26.7) | 15 (62.5) | 4 (10.8) |
| TNFic | 4 (26.7) | 5 (8.3) | 10 (41.7) | 1 (2.7) |
| Start at visit 1 T-2 T-3 T | 2-2-0 | 1-3-1 | 4-4-2 | 0-0-1 |
| Glucocorticosteroidsb | 5 (33.3) | 11(18.6) | 12 (50) | 3 (8.1) |
| Start at visit 1 T-2 T-3 T | 0-4-1 | 3-6-2 | 4-5-3 | 0-2-1 |
