RA | axSpA | |||
---|---|---|---|---|
TNFi until positive pregnancy testa (n = 15) | TNFi-negative (n = 60) | TNFi until positive pregnancy test (n = 24) | TNFi-negative (n = 37) | |
Patients (n) with flare at | ||||
First trimester | 6 | 4 | 1 | 2 |
Second trimester | 3 | 4 | 5 | 1 |
Third trimester | 1 | 4 | 4 | 2 |
Medication at conception | ||||
TNFi | 15 (100) | 0 (0) | 24 (100) | 0 (0) |
NSAIDs | 1 (6.7) | 13 (21.7) | 11 (45.8) | 23 (61.2) |
Glucocorticosteroidsb | 1 (6.7) | 23 (38.3) | 2 (8.3) | 1(3.7) |
DMARDs | 2 (13.3) | 27 (45) | 3 (12.5) | 2 (5.4) |
SSZ | 1 (6.7) | 17(28.3) | 3 (12.5) | 2 (5.4) |
HCQ | 1 (6.7) | 7 (11.7) | ||
SSZ and HCQ | 3 (5) | |||
Medication during pregnancy | ||||
TNFi | 4 (26.7) | 5 (8.3) | 10 (41.7) | 1 (2.7) |
NSAIDs | 5 (33.3) | 23 (38.3) | 15 (62.5) | 27 (73) |
Glucocorticosteroidsb | 7 (46.7) | 29 (48.3) | 12 (50.0) | 3 (8.1) |
DMARDs | 7 (46.7) | 38 (63.3) | 3 (12.5) | 2 (5.4) |
SSZ | 1 (6.7) | 23 (38.3) | 3 (12.5) | 2 (5.4) |
HCQ | 1 (6.7) | 9 (15) | ||
SSZ and HCQ | 5 (33.3) | 6 (10) | ||
Initiation of medication during pregnancy | 9 (60) | 16 (26.7) | 15 (62.5) | 4 (10.8) |
TNFic | 4 (26.7) | 5 (8.3) | 10 (41.7) | 1 (2.7) |
Start at visit 1 T-2 T-3 T | 2-2-0 | 1-3-1 | 4-4-2 | 0-0-1 |
Glucocorticosteroidsb | 5 (33.3) | 11(18.6) | 12 (50) | 3 (8.1) |
Start at visit 1 T-2 T-3 T | 0-4-1 | 3-6-2 | 4-5-3 | 0-2-1 |